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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT47 描述 Anti-Claudin-7 Antibody Alternate Names - CLDN-7
- Claudin-7
背景信息 Claudin-7 is a member of a family of claudins that are tight junction integral membrane proteins with four transmembrane domains and two extracellular loops. Claudin-7 has been shown to be under-expressed in invasive ductal carcinomas and colorectal carcinomas as compared to normal epithelial cells. Claudin-7 differs from other claudins because it has both structural and regulatory functions, regulating the expression of prostate specific antigen. 产品信息 格式 Affinity Purified 控制 - BALB3T3/A31 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Claudin-7 Antibody is an antibody against Claudin-7 for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Claudin-7. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 RatHumanMouse Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001171951
Entrez基因汇总 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found. 基因符号 - CPETRL2
- CLDN7
- CEPTRL2
纯化方法 Affinity Purified UniProt编号 - O95471
UniProt汇总 FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity).
SUBUNIT STRUCTURE: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM. Ref.10
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction › tight junction. Note: Co-localizes with EPCAM at the lateral cell membrane and tight junction.
TISSUE SPECIFICTY: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. INDUCTION: By androgens.
PTM: Phosphorylated.
SEQUENCE SIMILARITIES: Belongs to the claudin family.
SEQUENCE CAUTION: The sequence AAP97219.1 differs from that shown. Reason: Frameshift at positions 18 and 23.产品使用声明 质量保证 Evaluated by Western Blot in BALB3T3/A31 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Claudin-7 in 10 µg of BALB3T3/A31 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,14-730,c-Kit (V560G) Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,14-557M,B-Raf (V599E) Protein, active, 250 µg
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