- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,559303,SANT-1 - CAS 304909-07-7 - Calbiochem
产品名称：SANT-1 - CAS 304909-07-7 - Calbiochem
产品型号：559303
A potent, cell-permeable antagonist of the Shh signaling pathway by binding directly to Smoothened, a distant relative of G protein-coupled receptors.
merck millipore,默克密理博,559303,SANT-1 - CAS 304909-07-7 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₃H₂₇N₅ 304909-07-7 描述 概述 A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay). 产品目录编号 559303 品牌系列 Calbiochem®
同义词 Shh Signaling Antagonist V 参考 参考 Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.产品信息 CAS号 304909-07-7 具有ATP竞争性 N 形式 White solid Hill配方 C₂₃H₂₇N₅ 化学配方 C₂₃H₂₇N₅ Molar Mass 373.5 可逆 N 结构配方图像 生物信息 主靶 Shh (Sonic Hedgehog) signaling pathway 主靶IC50 20 nM as antagonist of the Shh (Sonic Hedgehog) signaling pathway in the Shh-LIGHT2 assay and in Ptch1-l- cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
From Catalog:
Desc. Field- added "cell-permeable包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,AP124C,Goat Anti-Mouse IgG Antibody, Cy3 conjugate
下一件merck millipore产品：merck millipore,默克密理博,506121,p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
相关产品
merck millipore,默克密理博,14-730,c-Kit (V560G) Protein, active, 10 µg
merck millipore,默克密理博,ABT47,Anti-Claudin-7 Antibody
merck millipore,默克密理博,14-557M,B-Raf (V599E) Protein, active, 250 µg
merck millipore,默克密理博,AP124C,Goat Anti-Mouse IgG Antibody, Cy3 conjugate
merck millipore,默克密理博,506121,p38 MAP Kinase Inhibitor III - CAS 581098-48-8 - Calbiochem
merck millipore,默克密理博,218809,Caspase Substrate Set IV, Fluorogenic - Calbiochem
merck millipore,默克密理博,SF-132,HPRT1; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,05-23-5501,Parathyroid Hormone 1-34, Human - CAS 52232-67-4 - Calbiochem
merck millipore,默克密理博,MAB1388Z,Anti-Integrin β2 Antibody, clone YFC118.3, azide free