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品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, H, M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD50 描述 Anti-BMPR-1B Antibody Alternate Names - CDw293
- Bone morphogenetic protein receptor type-1B
- BMP type-1B receptor
- BMPR-1B
背景信息 BMPR-1B (bone morphogenic protein receptor type 1B) is a serine-threonine kinase receptor expressed in granulosa cells. Increased expression of BMPR-1B has been linked to increased ovulation rates in some mammals. BMPR-1B has recently been associated with astrogliosis after a spinal cord injury. BMPR-1A and BMPR-1B work together to suppress ovarian tumorigenesis. 产品信息 格式 Affinity Purified 控制 - Human ovary tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-BMPR-1B Antibody is validated for use in WB for the detection of BMPR-1B. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 0.5 - 1 µg/mL from a representative lot detected BMPR-1B on 10 µg of mouse ovary tissue and L6 cell lysates. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human BMPR-1B. 表位 Cytoplasmic domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes BMPR-1B at the cytoplasmic domain. 品种反应性 Rhesus MacaqueHumanMouseRat Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001194
Entrez基因汇总 This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq]. 基因符号 - BMPR1B
纯化方法 Affinity purified UniProt编号 - O00238
UniProt汇总 FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5.
CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
COFACTOR: Magnesium or manganese (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
INVOLVEMENT IN DISEASE: Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies (AMDGA) [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers).
Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by Western Blot in human ovary tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected BMPR-1B on 10 µg of human ovary tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,07-2188,Anti-phospho LRP-6 Antibody (Ser1607)
下一件merck millipore产品：merck millipore,默克密理博,04-1100,Anti-Smad1 Antibody, clone EP565Y, rabbit monoclonal
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