merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4399,Anti-CD133 (Prominin-1) Antibody, clone 17A6.1

  • merck millipore,默克密理博,MAB4399,Anti-CD133 (Prominin-1) Antibody, clone 17A6.1

    产品名称：Anti-CD133 (Prominin-1) Antibody, clone 17A6.1
    产品型号：MAB4399
    Detect CD133 (Prominin-1) using this Anti-CD133 (Prominin-1) Antibody, clone 17A6.1 validated for use in Western Blot (WB) & Immunohistochemistry (IHC).

    merck millipore,默克密理博,MAB4399,Anti-CD133 (Prominin-1) Antibody, clone 17A6.1

  • 产品介绍
  • merck millipore,默克密理博,MAB4399,Anti-CD133 (Prominin-1) Antibody, clone 17A6.1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4399
    描述 Anti-CD133 (Prominin-1) Antibody, clone 17A6.1
    Alternate Names
    • CD133
    • Prominin-1
    • Antigen AC133
    • Prominin-like protein 1
    背景信息 CD133 (Prominin-1) belongs to a family of cell-surface glycoproteins harboring five transmembrane domains, and is found in both normal cells and in several tumor and cancer cell types. In epithelial cells, particularly neuroepithelial stem cells, CD133 was found in the microvilli, primary cilium, and midbody. These three types of apical membrane protrusions are subject to remodeling during epithelial and neuroepithelial cell differentiation. CD133 may play a key role in apical plasma membrane organization in epithelial cells. CD133 acts a regulator of disk morphogenesis in early retinal development and also suppresses cell differentiation in a RET-dependent manner in neuroblastoma cells. Overexpression of this glycoprotein has been reported in acute myelogenous leukaemia, acute lymphocytic leukaemia, chronic lymphocytic leukaemia, myelodysplastic syndromes, retinoblastomas, glioblastomas and kidney carcinomas. High levels of CD133 were also found in pancreatic, gastric, colorectal, and hepatocellular cancers.
    产品信息
    格式 Purified
    控制
    • Recombinant CD133 (Prominin-1).
    演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect CD133 (Prominin-1) using this Anti-CD133 (Prominin-1) Antibody, clone 17A6.1 validated for use in Western Blot (WB) & Immunohistochemistry (IHC).
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected CD133 (Prominin-1) in human glioblastoma cells.
    生物信息
    免疫原品种 Recombinant protein corresponding to human CD133 (Prominin-1).
    克隆 17A6.1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG2aκ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001139319
    Entrez基因汇总 This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • MSTP061
    • PROM1
    • PROML1
    纯化方法 Protein G Purified
    UniProt编号
    • O43490
    UniProt汇总 FUNCTION: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.

    SUBUNIT STRUCTURE: Interacts with CDHR1 and with actin filaments.

    SUBCELLULAR LOCATION: Cell projection > cilium > photoreceptor outer segment. Isoform 1: Apical cell membrane; Multi-pass membrane protein. Cell projection > microvillus membrane; Multi-pass membrane protein. Note: Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.

    TISSUE SPECIFICITY: Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).
    产品使用声明
    质量保证 Evaluated by Western Blot in CD133 (Prominin-1) recombinant protein.

    Western Blot Analysis: 0.2 µg/mL of this antibody detected CD133 (Prominin-1) in 2.5 µg of recombinant CD133 (Prominin-1).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4399,Anti-CD133 (Prominin-1) Antibody, clone 17A6.1

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