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merck millipore,默克密理博,420144,JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem
产品名称：JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem
产品型号：420144
The JNK Inhibitor XIII, also referenced under CAS 40045-50-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicati More>>
merck millipore,默克密理博,420144,JNK Inhibitor XIII - CAS 40045-50-9 - Calbiochem
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重要规格表
经验配方 CAS号 C₅H₃N₅O₂S₃ 40045-50-9 描述 概述 A cell-permeable non-peptidyl thiazolyl-thiadiazole alternative to pepJIP1 (TI-JIP1153-163) and TAT-pepJIP1 (Cat. Nos. 420133 & 420134, respectively) as a JIP-docking site-targeting (IC50 = 239 nM against pepJIP1 binding to JNK1) and substrate-competitive JNK inhibitor (IC50 = 700 nM against ATF2 phosphorylation by JNK1), while exhibiting little activity (IC50 >50 µM) toward p38α, Akt, furin, or lethal factor. Shown to inhibit the phosphorylation of overexpressed GFP-c-Jun in HeLa cultures upon TNF-α stimulation (IC50 = 6.23 µM) in vitro and restore insulin sensitivity in a murine of type-2 diabetes model (25 mg/kg, i.p.) in vivo. Biostability analysis with rat liver microsome preparations results in a compound half-life of 27 min at 37.5°C. 产品目录编号 420144 品牌系列 Calbiochem®
同义词 5-(5-Nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine 参考 参考 De, S.K., et al. 2009. J. Med. Chem. 52, 1943. 产品信息 CAS号 40045-50-9 形式 Pale yellow solid Hill配方 C₅H₃N₅O₂S₃ 化学配方 C₅H₃N₅O₂S₃ Molar Mass 261.3 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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