merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB4371,Anti-SNAI2 Antibody, clone 2B6

  • merck millipore,默克密理博,MAB4371,Anti-SNAI2 Antibody, clone 2B6

    产品名称：Anti-SNAI2 Antibody, clone 2B6
    产品型号：MAB4371
    Anti-SNAI2 Antibody, clone 2B6 detects level of SNAI2 & has been published & validated for use in WB.

    merck millipore,默克密理博,MAB4371,Anti-SNAI2 Antibody, clone 2B6

  • 产品介绍
  • merck millipore,默克密理博,MAB4371,Anti-SNAI2 Antibody, clone 2B6

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB4371
    描述 Anti-SNAI2 Antibody, clone 2B6
    Alternate Names
    • snail homolog 2 (Drosophila)
    • Neural crest transcription factor Slug
    • Protein snail homolog 2
    • slug (chicken homolog), zinc finger protein
    • slug homolog, zinc finger protein
    • slug homolog, zinc finger protein (chicken)
    • snail 2
    背景信息 SNAI2 (snail homolog 2) is a neurogenic transcription factor belonging to the SNAIL family and is implicated in both the epithelial-mesenchymal transition and cell survival, as well as in important morphogenetic processes during embryo development and tumor metastasis. Through studies done in chick embryo, this protein has also been identified in the neural crest and in mesodermal cells emigrating from the primitive streak. In addition, SNAI2 has been found to be a key contributor to the function of the stem cell factor/c-kit signaling pathway, and mediates the radioresistance biological function of SCF/c-kit. Consequently, alterations to this gene have been associated to different human syndromes. SNAI2 is predominately expressed in placenta, melanocytes, and differentiating embryonic stem cells, as well as in adult heart, pancreas, liver, kidney, skeletal muscle.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4) and 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-SNAI2 Antibody, clone 2B6 detects level of SNAI2 & has been published & validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Synthetic human SNAI2 peptide, a.a. 97-169.
    克隆 2B6
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This monoclonal antibody recognizes the SNAI2 protein.
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Reacts with human. Reactivity with other species has not been tested.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • O43623
    基因符号
    • WS2D
    • MGC10182
    • OTTHUMP00000195093
    • SLUG
    • SLUGH
    • SLUGH1
    纯化方法 Protein G purfied
    UniProt编号
    • O43623
    UniProt汇总 FUNCTION: Transcriptional repressor. Involved in the generation and migration of neural crest cells.

    SUBCELLULAR LOCATION: Nucleus Probable.

    TISSUE SPECIFICITY: Expressed in placenta and adult heart, pancreas, liver, kidney and skeletal muscle.

    INVOLVEMENT IN DISEASE: Defects in SNAI2 are a cause of neural tube defects (NTD).

    Defects in SNAI2 are the cause of Waardenburg syndrome type 2D (WS2D) [MIM:608890]. WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.

    SEQUENCE SIMILARITIES: Belongs to the snail C2H2-type zinc-finger protein family.

    Contains 5 C2H2-type zinc fingers.
    产品使用声明
    质量保证 (Based upon representative data from a previous lot).

    Western Blotting: Recommended working dilution is 1-2 µg/mL.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB4371,Anti-SNAI2 Antibody, clone 2B6

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