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merck millipore,默克密理博,676495,VEGF Inhibitor, V1 - Calbiochem
产品名称：VEGF Inhibitor, V1 - Calbiochem
产品型号：676495
The VEGF Inhibitor, V1 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,676495,VEGF Inhibitor, V1 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₄₀H₆₁N₁₁O₉ 描述 概述 An NRP-1-binding heptapeptide whose target was initially mistaken as VEGFR2/KDR/Flk-1 due to its binding activity to a CHO-KDR culture that was later shown to express primarily NRP-1 and little KDR. V1/A7R specifically competes against VEGF165 binding to recombinant NRP-1 in cell-free binding assays (IC50 = 60 µM), while exhibiting no activity against the interaction between NRP-1 and heparin or VEGF165 binding to KDR, VEGFR1/Flt-1, and heparin. V1/A7R is demonstrated to inhibit VEGF-dependent angiogenesis activity in HMVEC (IC50 = 0.3 µM) and HUVEC cultures in vitro, as well as in a rabbit corneal neovascularization model and in mice bearing MDA-MB-231-derived tumor in vivo. 产品目录编号 676495 品牌系列 Calbiochem®
同义词 ATWLPPR 参考 参考 Starzec, A., et al. 2006. Life Sci. 79, 2370.
Binetruy-Tournaire, R., et al. 2000. EMBO J. 19, 1525.产品信息 具有ATP竞争性 N 形式 White lyophilized solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₄₀H₆₁N₁₁O₉ 化学配方 C₄₀H₆₁N₁₁O₉ Molar Mass 840.0 吸湿 Hygroscopic
肽序列 H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH 可逆 N 生物信息 主靶 Specifically competes against VEGF165 binding to recombinant NRP-1 主靶IC50 60 µM for specifically competes against VEGF165 binding to recombinant NRP-1 in cell-free binding assays 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 肽序列 H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,MAB4371,Anti-SNAI2 Antibody, clone 2B6
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