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merck millipore,默克密理博,MAB3890,Anti-PPAR α Antibody
产品名称：Anti-PPAR α Antibody
产品型号：MAB3890
Use Anti-PPAR α Antibody (Mouse Monoclonal Antibody) validated in ELISA, WB, ICC to detect PPAR alpha also known as Peroxisome Proliferator Activated Receptor α.
merck millipore,默克密理博,MAB3890,Anti-PPAR α Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, ELISA, WB M Ascites Monoclonal Antibody 描述 产品目录编号 MAB3890 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-PPAR α Antibody Alternate Names - PPAR alpha
背景信息 Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARα, PPARβ (also designated PPARδ) and PPARγ, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARα is abundant in primary hepatocytes where it regulates the expression of proteins involved in fatty acid metabolism. PPARβ is the most widely distributed subtype and is often expressed at high levels. PPARγ is predominantly seen in adipose tissue where it plays a critical role in regulating adipocyte differentiation. 产品信息 格式 Ascites 控制 - 3T3 whole cell lysate
演示 Ascites fluid. Liquid. Contains no preservative. 应用 应用 Use Anti-PPAR α Antibody (Mouse Monoclonal Antibody) validated in ELISA, WB, ICC to detect PPAR alpha also known as Peroxisome Proliferator Activated Receptor α. 主要应用 - Immunocytochemistry
- ELISA
- Western Blotting
应用说明 Western blot: 1:500-1:5,000
Immunocytochemistry: 1:500-1:5,000
ELISA: 1:500-1:5,000
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide from amino acids 18-34 of mouse PPARalpha. 宿主 Mouse 特异性 Reacts with Peroxisome Proliferator Activated Receptor alpha (PPARalpha). No cross reactivity with PPARbeta or PPARgamma. 同种型 IgG2a 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005036.4
- NM_001001929.2
- NM_001001930.2
- NM_032644.3
- NM_001001928.2
Entrez基因汇总 Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. 基因符号 - MGC2237
- PPARA
- PPAR
- OTTHUMP00000042872
- hPPAR
- MGC2452
- OTTHUMP00000028713
- NR1C1
- PPAR-alpha
UniProt编号 - Q07869
UniProt汇总 FUNCTION: SwissProt: Q07869 # Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.
SIZE: 468 amino acids; 52225 Da
SUBUNIT: Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Skeletal muscle, liver, heart and kidney.
SIMILARITY: SwissProt: Q07869 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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