merck millipore,默克密理愽
  • merck millipore,默克密理博,04-002-C,Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)

  • merck millipore,默克密理博,04-002-C,Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)

    产品名称：Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)
    产品型号：04-002-C
    This Anti-SOCS1 Antibody, clone 4H1 (Ascites Free) is validated for use in western blotting & IP for the detection of SOCS1.

    merck millipore,默克密理博,04-002-C,Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)

  • 产品介绍
  • merck millipore,默克密理博,04-002-C,Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-002-C
    商名
    • Upstate
    描述 Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)
    Alternate Names
    • SSI-1
    • Suppressor of cytokine signaling 1
    • SOCS-1
    • JAK-binding protein
    • JAB
    • STAT-induced STAT inhibitor 1
    背景信息 SOCS1, also known as Suppressor of cytokine signaling 1, or JAK-binding protein (JAB), STAT-induced STAT inhibitor 1 (SSI-1), or Tec-interacting protein 3 (TIP3), and encoded by the gene SOCS1/CISH1/SSI1/TIP3, is involved in the negative regulation of cytokines signaling that is mediated by several kinases including JAKs, TEC, KIT, GRB2 and VAV kinases. SOCS1 inhibits kinase activity via binding to the target kinase. SOCS1 also appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF), and SOCS1regulates interferon-gamma mediated sensory neuron survival and is a negative regulator in IGF1R signaling pathway. Finally, SOCS1 forms the substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. SOCS1 is localized to the nucleus and cytoplasmic vesicles. SOCS1 is expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-SOCS1 Antibody, clone 4H1 (Ascites Free) is validated for use in western blotting & IP for the detection of SOCS1.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot of this antibody immunoprecipitated SOCS1 in cell lysates.
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to mouse SOCS1.
    克隆 4H1
    浓缩 1 mg/mL
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Human. Predicted to react with Mouse based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001258532
    基因符号
    • Ssi1
    • Socs1
    • Cish1
    纯化方法 Protein G purified
    UniProt编号
    • O35716
    产品使用声明
    质量保证 Evaluated by Western Blotting in KG-1 cell lysate.

    Western Blotting Analysis: 0.5 µg/mL of this antibody detected SOCS1 in 10 µg of KG-1 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,04-002-C,Anti-SOCS1 Antibody, clone 4H1 (Ascites Free)

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