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merck millipore,默克密理博,371963,H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem
产品名称：H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem
产品型号：371963
A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM).
merck millipore,默克密理博,371963,H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₀H₂₀BrN₃O₂S · 2HCl 127243-85-0 描述 概述 A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7 µM), casein kinase I (Ki = 38.3 µM), myosin light chain kinase (Ki = 28.3 µM), protein kinase C (Ki = 31.7 µM), and ROCK-II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. A 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371962) in DMSO is also available. 产品目录编号 371963 品牌系列 Calbiochem®
同义词 N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III 参考 参考 Leemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
Davies, S.P., et al. 2000. Biochem. J. 351, 95.
Kawasaki, H., et al. 1998. Science 282, 2275.
de Rooij, J., et al. 1998. Nature 396, 474.
Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
Geilen, C.C. 1992. FEBS Lett. 309, 381.
Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.产品信息 CAS号 127243-85-0 具有ATP竞争性 Y 形式 Clear to off-white crystalline film Hill配方 C₂₀H₂₀BrN₃O₂S · 2HCl 化学配方 C₂₀H₂₀BrN₃O₂S · 2HCl Molar Mass 519.3 可逆 Y 结构配方图像 生物信息 主靶 PKA 主靶Ki 48 nM for protein kinase A 纯度 ≥99% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for at up to 4 months at 4°C. 包装信息 惰性气体下包装 Packaged under inert gas
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