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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 AB10302 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-PXR Antibody Alternate Names - Pregnane X receptor
背景信息 Pregnane X receptor (PXR) is a nuclear receptor and is similar in form to PPAR and RXR. PXR is activated by a large number of endogenous and exogenous chemicals including steroids and antibiotics. One of the key roles of PXR is the induction of CYP3A4, an P450 enzyme that is responsible for the metabolism of many drugs. 产品信息 格式 Serum 演示 Raw rabbit serum with 0.1% sodium azide. 应用 应用 Anti-PXR Antibody is an antibody against PXR for use in WB. 主要应用 - Western Blotting
应用说明 Suggested dilutions:
Western Blot: 1:5000生物信息 免疫原品种 Recombinant human hPXR 宿主 Rabbit 同种型 IgG2b 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_033013.2
- NM_003889.3
- NM_022002.2
Entrez基因汇总 This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. 基因符号 - PARq
- NR1I2
- PAR
- PRR
- SAR
- ONR1
- PAR1
- BXR
- SXR
- PXR
- PAR2
UniProt编号 - O75469
UniProt汇总 FUNCTION: SwissProt: O75469 # Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics.
SIZE: 434 amino acids; 49762 Da
SUBUNIT: Forms a heterodimer with RXR.
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Expressed in liver, colon and small intestine.
SIMILARITY: SwissProt: O75469 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to 12 months from date of receipt. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,371963,H-89, Dihydrochloride - CAS 127243-85-0 - Calbiochem
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