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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3783 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Cullin 1 Antibody, clone AS97.1 Alternate Names - CUL-1
背景信息 Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle. 产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25M NaCl, pH 7.6, with 0.1% sodium azide 应用 应用 Detect Cullin 1 using this Anti-Cullin 1 Antibody, clone AS97.1 validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Recombinant human Cullin-1 克隆 AS97.1 宿主 Mouse 特异性 Recognizes human and mouse Cullin-1. 同种型 IgG2a 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_003592.2
基因符号 - Cullin-1
- CUL1
- MGC149835
- CUL-1
- MGC149834
UniProt编号 - Q13616
UniProt汇总 FUNCTION: SwissProt: Q13616 # Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.
SIZE: 776 amino acids; 89679 Da
SUBUNIT: Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2, where it interacts directly with SKP1, SKP2 and RBX1. Interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with COPS2.
TISSUE SPECIFICITY: Expressed in lung fibroblasts.
PTM: Neddylated; which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.
SIMILARITY: SwissProt: Q13616 ## Belongs to the cullin family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,ABT147,Anti-Claudin-1 Antibody
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