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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Sh Purified Polyclonal Antibody 描述 产品目录编号 06-548 品牌系列 Upstate
商名 - Upstate
描述 Anti-SLP 76 Antibody 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.5, 150mM NaCl, and 0.05% sodium azide 应用 应用 This Anti-SLP 76 Antibody is validated for use in IF, IP, WB for the detection of SLP 76. 主要应用 - Western Blotting
生物信息 免疫原品种 Bacterially expressed human GST-SLP 76 fusion protein 宿主 Sheep 特异性 SLP 76 同种型 IgG 品种反应性 MouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005565
Entrez基因汇总 SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. 基因符号 - SLP76
- LCP2
- SLP-76
纯化方法 Protein G chromatography UniProt编号 - Q13094
UniProt汇总 FUNCTION: SwissProt: Q13094 # Involved in T-cell antigen receptor mediated signaling.
SIZE: 533 amino acids; 60188 Da
SUBUNIT: Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1.
SUBCELLULAR LOCATION: Cytoplasm (Probable).
TISSUE SPECIFICITY: Highly expressed in spleen, thymus, and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblasatoma cell lines.
DOMAIN:SwissProt: Q13094 The SH2 domain mediates interaction with SHB.
PTM: Phosphorylated after T-cell receptor activation by ZAP-70.
SIMILARITY: Contains 1 SH2 domain.产品使用声明 质量保证 routinely evaluated by immunoblot on RIPA lysates from Jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 250 µg
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下一件merck millipore产品：merck millipore,默克密理博,05-505,Anti-IQGAP2 Antibody, clone BB9
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