merck millipore,默克密理愽
  • merck millipore,默克密理博,526526,PIM3 Kinase Inhibitor VII, M-110 - Calbiochem

  • merck millipore,默克密理博,526526,PIM3 Kinase Inhibitor VII, M-110 - Calbiochem

    产品名称：PIM3 Kinase Inhibitor VII, M-110 - Calbiochem
    产品型号：526526


    merck millipore,默克密理博,526526,PIM3 Kinase Inhibitor VII, M-110 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,526526,PIM3 Kinase Inhibitor VII, M-110 - Calbiochem

    重要规格表

    经验配方
    C₂₂H₂₈ClN₅O₃
    描述
    概述 A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki = 0.3 µM), and highly isoform-selective PIM inhibitor (IC50 = 2.5, 2.5, and 0.047 µM against PIM1, PIM2, and PIM3, respectively; [ATP] = 10 µM), while affecting CK2α2 only at much higher concentrations (IC50 = 5 µM, [ATP] = 10 µM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition at 5 µM). Shown to inhibit PIM3-dependent STAT3 Tyr705 phosphorylation in DU-145 prostate cancer and MiaPaCa2 pancreatic cancer cells (by 73% and 83%, respectively; 10 µM for 18 h), while displaying little effect toward STAT3 Tyr694 phosphoylation in 22RV1 cultures.
    产品目录编号 526526
    品牌系列 Calbiochem®
    同义词 Nʹ-(1-(4-Chloro-2-hydroxyphenyl)propylidene)-2-((3-morpholinopropyl)amino)isonicotinohydrazide
    参考
    参考 Chang, M., et al. 2010. Mol. Cancer Ther. 9, 2478.
    产品信息
    形式 Pale yellow solid
    Hill配方 C₂₂H₂₈ClN₅O₃
    化学配方 C₂₂H₂₈ClN₅O₃
    Molar Mass 445.9
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,526526,PIM3 Kinase Inhibitor VII, M-110 - Calbiochem

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