merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3658,Anti-TATA-Binding-Protein Antibody

  • merck millipore,默克密理博,MAB3658,Anti-TATA-Binding-Protein Antibody

    产品名称：Anti-TATA-Binding-Protein Antibody
    产品型号：MAB3658
    Anti-TATA-Binding-Protein Antibody is a Mouse Monoclonal Antibody for detection of TATA-Binding-Protein also known as TBP & has been validated in WB, ICC & IHC.

    merck millipore,默克密理博,MAB3658,Anti-TATA-Binding-Protein Antibody

  • 产品介绍
  • merck millipore,默克密理博,MAB3658,Anti-TATA-Binding-Protein Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    F, Ch, H, M, XnIHC, WB, ICCMAscitesMonoclonal Antibody
    描述
    产品目录编号 MAB3658
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-TATA-Binding-Protein Antibody
    Alternate Names
    • TBP
    产品信息
    格式 Ascites
    演示 Ascites. Liquid. Contains no preservative.
    应用
    应用 Anti-TATA-Binding-Protein Antibody is a Mouse Monoclonal Antibody for detection of TATA-Binding-Protein also known as TBP & has been validated in WB, ICC & IHC.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    应用说明 Western blot: 1:1,000-1:5,000 on endogenous and recombinant protein.

    Immunohistochemistry: 1:1,000-1:5,000

    Immunocytochemistry: 1:1,000-1:5,000

    Immunoprecipitation

    ELISA: 1:1,000-1:5,000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Full length recombinant human TBP.
    表位 a.a. 1-18
    宿主 Mouse
    特异性 Recognizes TATA-binding-protein (TBP). Recognizes an epitope from the first 18 amino acids of human TBP.
    同种型 IgG1
    品种反应性 FishChickenHumanMouseXenopus
    Species Reactivity Note Human, mouse, chicken, xenopus and zebrafish. Does not react with Drososphila. Reactivity with other species has not been confirmed.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003194.3
    Entrez基因汇总 Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
    基因符号
    • MGC126054
    • TBP
    • MGC126055
    • SCA17
    • GTF2D1
    • TFIID
    • TF2D
    • MGC117320
    • GTF2D
    非反应性品种
    • Drosophila
    纯化方法 Unpurified
    UniProt编号
    • P20226
    UniProt汇总 FUNCTION: SwissProt: P20226 # General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.
    SIZE: 339 amino acids; 37698 Da
    SUBUNIT: Belongs to the TFIID complex together with the TBP- associated factors (TAFs). Component of the transcription factor SL1/TIFIB complex, composed of TBP and at least TAF1A, TAF1B TAF1C, and TAF3. Binds DNA as monomer. Interacts with TAFs, TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with HIV-1 Tat. Interacts with UTF1 which acts as a coactivator of ATF2 transcriptional activity.
    SUBCELLULAR LOCATION: Nucleus.
    DISEASE: SwissProt: P20226 # Defects in TBP are the cause of spinocerebellar ataxia 17 (SCA17) [MIM:607136]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of autosomal dominant cerebellar ataxias (ADCA). Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements. Spinocerebellar ataxia is caused by degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
    SIMILARITY: SwissProt: P20226 ## Belongs to the TBP family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MAB3658,Anti-TATA-Binding-Protein Antibody

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