merck millipore,默克密理愽
  • merck millipore,默克密理博,616463,TGF-β RI Kinase Inhibitor IX - Calbiochem

  • merck millipore,默克密理博,616463,TGF-β RI Kinase Inhibitor IX - Calbiochem

    产品名称：TGF-β RI Kinase Inhibitor IX - Calbiochem
    产品型号：616463


    merck millipore,默克密理博,616463,TGF-β RI Kinase Inhibitor IX - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616463,TGF-β RI Kinase Inhibitor IX - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₈N₄O₃S
    描述
    概述 A cell-permeable pyridinyloxypyridine compound that acts as a potent and highly selective inhibitor against TGFβ RI/ALK5 (IC50 = 72 nM, [ATP] = 1 mM) by targeting both the ATP-binding site and the “selectivity pocket”, while exhibiting much reduced or little activity against a panel of 75 other kinases (IC50 <1 µM). Shown to reduce TGFβ1-induced nuclear translocation of a GFP-Smad2 fusion reporter in MDA-MB-468 cells (IC50 = 22 nM) in vitro and exhibit excellent oral bioavailability (F = 75%, AUC = 4.95 µM.h) with low clearance (12 ml/min/kg) in rats in vivo.
    产品目录编号 616463
    品牌系列 Calbiochem®
    同义词 4-((4-((2,6-Dimethylpyridin-3-yl)oxy)pyridin-2-yl)amino)benzenesulfonamide, ALK5 Inhibitor IX
    参考
    参考 Goldberg, F.W., et al. 2009. J. Med. Chem. 52, 7901.
    产品信息
    形式 Off-white powder
    Hill配方 C₁₈H₁₈N₄O₃S
    化学配方 C₁₈H₁₈N₄O₃S
    Molar Mass 370.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstiution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616463,TGF-β RI Kinase Inhibitor IX - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,189510,Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,420123,JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem


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