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  • merck millipore,默克密理博,ABE415,Anti-Transcription factor EB Antibody

  • merck millipore,默克密理博,ABE415,Anti-Transcription factor EB Antibody

    产品名称：Anti-Transcription factor EB Antibody
    产品型号：ABE415
    Detect TFEB using this rabbit polyclonal antibody, Anti-Transcription factor EB Antibody validated for use in western blotting & IP.

    merck millipore,默克密理博,ABE415,Anti-Transcription factor EB Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE415,Anti-Transcription factor EB Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE415
    描述 Anti-Transcription factor EB Antibody
    Alternate Names
    • bHLHe35
    • Transcripiton factor EB
    • Class E basic helix-loop-helix protein 35
    背景信息 The protein named Transcription factor EB (TFEB) or alternatively in older literature, Class E basic helix-loop-helix protein 35 (bHLHe35) and encoded by the human gene TFEB/BHLH35 is a transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') on DNA. Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. TFEB in association with the protein TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB also plays a central role in expression of lysosomal genes. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes and through binding acts as a positive regulator of their expression. Finally, TFEB appears to be a positive regulator for autophagy related gene expression, heavy chain immunoglobulin gene expression, and genes necessary for the proper vascularization of important tissues such as the placenta.
    产品信息
    格式 Affinity Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Detect TFEB using this rabbit polyclonal antibody, Anti-Transcription factor EB Antibody validated for use in western blotting & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated Transcription factor EB in 500 µg of Raji cell lysate. Immunopecipitated Transcription factor EB was then detected in Western Blot.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to a region near the C-terminus of human Transcription factor EB.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rhesus Macaque, Gibbon, Orangutan, Baboon, and Chimpanzee based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_009093
    基因符号
    • BHLHE35
    • TFEB
    纯化方法 Affinity purified
    UniProt编号
    • P19484
    产品使用声明
    质量保证 Evaluated by Western Blotting in Raji cell lysate.

    Western Blotting Analysis: 1 µg/mL of this antibody detected Transcription factor EB in 10 µg of Raji cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE415,Anti-Transcription factor EB Antibody

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