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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS26 描述 Anti-MNBH Antibody Alternate Names - dual-specificity tyrosine-Y-phosphorylation regulated kinase, EC 2.7.19
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- dual specificity tyrosine-phosphorylation-regulated kinase 1A
- mnb protein kinase homolog hp86
- Dual specificity YAK1-related kinase
- serine/threonine kinase MNB
- Protein kinase minibrain homolog
- MNB/DYRK protein kinase
- serine/threonine-specific protein kinase
背景信息 Minibrain (MNBH) is also known as DYRK1 and is the human homolog of the mnb gene in Drosophila and is mapped on human chromosome 21q22.2, which is within the down syndrome critical region. MNBH may be involved in the signaling pathway that controls cell proliferation and is thought to regulate neuronal differentiation and apoptosis by phosphorylating Hip-1. 产品信息 格式 Affinity Purified 控制 - NIH/3T3 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MNBH Antibody is an antibody against MNBH for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the N-terminus of human MNBH. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes MNBH at the N-terminus. 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human and Mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001387
Entrez基因汇总 This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq]. 基因符号 - MNB
- DYRK1A
- HP86
- DYRK
- DYRK1
- MNBH
- hMNB
纯化方法 Affinity purified UniProt编号 - Q13627
UniProt汇总 FUNCTION: May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Inhibited by RANBP9.
SUBUNIT STRUCTURE; Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9. Interacts with WDR68.
SUBCELLULAR LOCATION: Nucleus speckle.
TISSUE SPECIFICITY: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.
DEVELOPMENTAL STAGE: Expressed in the developing central nervous system. Overexpressed 1.5-fold in fetal Down syndrome brain.
PTM: Autophosphorylated on tyrosine residues.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by Western Blot in NIH/3T3 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected MNBH on 10 µg of NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,420123,JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,05-1308,Anti-Ubiquitin Antibody, Lys63-Specific, clone Apu3, rabbit monoclonal
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