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merck millipore,默克密理博,189510,Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem
产品名称：Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem
产品型号：189510
The Autotaxin Inhibitor I, S32826, also referenced under CAS 1103672-43-0, controls the biological activity of Autotaxin.
merck millipore,默克密理博,189510,Autotaxin Inhibitor I, S32826 - CAS 1103672-43-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₃₄NO₄PNa₂ • 2H₂O 1103672-43-0 描述 概述 A phosphonate compound that potently inhibits both the phosphodiesterase (IC50 = 9 nM in pNppp assay using ATX β) and the lysoPLD (IC50 = 5.6 nM and 47 nM, by enzyme-linked fluorescence detection or autoradiography by TLC, respectively, using ATX β) activities of ATX α/β/γ, while exhibiting much reduced (IC50 ~ 6 µM and 15 µM against Src and PTP-1B, respectively) or little activity toward 29 other receptors and enzymes. Shown to block LPA release from murine 3T3F422A adipocytes (IC50 = 90 nM) in vitro and from excised human and rat adipose tissues (by ~70% inhibition at 0.2 and 1 µM, respectively) in cultures ex vivo. The in vivo applicability of S32826 is limited by its low epithelial permeability and other poor pharmacokinetic properties. CTAB (Cat. No. 219374) is reported to counteract the inhibitory activity of S32826, 2-methyl-2,4-pentanediol can be used instead to stabilize purified enzyme in solution during S32826 inhibition assays. 产品目录编号 189510 品牌系列 Calbiochem®
同义词 ATX Inhibitor I, (4-(Tetradecanoylamino)benzyl)phosphonic acid disodium, dihydrate 参考 参考 Boutin, J.A., and Ferry, G. 2009. Cell Mol. Life Sci. 66, 3009.
Samadi, N., et al. 2009. Oncogene 28, 1028.
Ferry, G., et al. 2008. J. Pharm. Exp. Ther. 327, 809.产品信息 CAS号 1103672-43-0 形式 White powder Hill配方 C₂₁H₃₄NO₄PNa₂ • 2H₂O 化学配方 C₂₁H₃₄NO₄PNa₂ • 2H₂O Molar Mass 477.5 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 H₂O 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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