merck millipore,默克密理博,MAB3418X,Anti-MAP2 Antibody, Alexa Fluor 488 conjugated

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merck millipore,默克密理博,MAB3418X,Anti-MAP2 Antibody, Alexa Fluor 488 conjugated
产品名称：Anti-MAP2 Antibody, Alexa Fluor 488 conjugated
产品型号：MAB3418X
This Anti-MAP2 Antibody, Alexa Fluor 488 conjugated is validated for use in IH for the detection of MAP2.

merck millipore,默克密理博,MAB3418X,Anti-MAP2 Antibody, Alexa Fluor 488 conjugated

产品介绍

merck millipore,默克密理博,MAB3418X,Anti-MAP2 Antibody, Alexa Fluor 488 conjugated

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
R, B, Ch, H, M	IHC	M	AlexaFluor®488	Monoclonal Antibody

描述
产品目录编号	MAB3418X
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-MAP2 Antibody, Alexa Fluor® 488 conjugated

产品信息
格式	AlexaFluor®488
控制	Brain, Neuronal culture, Human glioblastoma T98G cells
演示	Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in Phosphate buffer with 15 mg/mL BSA as a stabilizer and 0.1% sodium azide.

应用
应用	This Anti-MAP2 Antibody, Alexa Fluor 488 conjugated is validated for use in IH for the detection of MAP2.
主要应用	Immunohistochemistry
应用说明	Immunohistochemistry Optimal working dilutions must be determined by end user. APPLICATION NOTES: Immunohistochemistry: Anti-MAP-2 can be used to stain tissue (brain or spinal cord) fixed with paraformaldehyde.

生物信息
免疫原品种	Bovine brain microtubule protein.
克隆	AP20
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	Recognizes MAP-2 (microtubule associated protein-2). MAP-2 is one of several high molecular weight proteins that play an important role in brain microtubule assembly. In addition to its association with microtubules, MAP-2 associates with neurofilaments and actin filaments suggesting that it may guide interaction among microtubules, other cytoskeletal elements, and cytoplasmic organelles (1). MAP-2 is a stringent marker for neurons. In addition, MAP-2 displays intracellular specificity. In the central nervous system, MAP-2 is confined to neuronal cell bodies and dendrites. There are exceptions, however, where some axons stain positive for small amounts of MAP-2 (2,3). MAP-2 is uniformly distributed throughout the cell when first expressed in cultured neurons but becomes selectively localized as dendritic development proceeds (4,5). SDS-PAGE Profiles: In SDS-PAGE MAP-2 from adult rat migrates as a closely associated doublet having a molecular weight of approximately 300 kD. However, early in brain development (postnatal day 10 in rats), MAP-2 migrates as a single band that is identical to the lower molecular weight band of the adult MAP-2 doublet (MAP-2b). Later in development (postnatal days 17-18), the mobility of MAP-2 changes to the adult doublet form. (In the spinal cord, conversion to the adult form occurs earlier).
同种型	IgG1
品种反应性	RatBovineChickenHumanMouse
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_031847.2 NM_001039538.1 NM_002374.3 NM_031845.2
Entrez基因汇总	This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described.
基因符号	MAP2A MAP2 MAP2B MAP-2 MAP2C DKFZp686I2148
纯化方法	Protein A purfied
UniProt编号	P11137
UniProt汇总	FUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. SIZE: 1827 amino acids; 199539 Da PTM: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: SwissProt: P11137 ## Contains 3 Tau/MAP repeats.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

产品使用声明

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

储存和货运信息
存储条件	Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

包装信息
数量	100 µg

merck millipore,默克密理博,MAB3418X,Anti-MAP2 Antibody, Alexa Fluor 488 conjugated

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