merck millipore,默克密理博,14-303M,MKK6/SKK3 Protein, active, 250 µg

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merck millipore,默克密理博,14-303M,MKK6/SKK3 Protein, active, 250 µg
产品名称：MKK6/SKK3 Protein, active, 250 µg
产品型号：14-303M
Active, N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end. For use in Kinase Assays.

merck millipore,默克密理博,14-303M,MKK6/SKK3 Protein, active, 250 µg

产品介绍

merck millipore,默克密理博,14-303M,MKK6/SKK3 Protein, active, 250 µg

描述
产品目录编号	14-303M
品牌系列	Upstate
商名	Upstate
描述	MKK6/SKK3 Protein, active, 250 µg
概述	N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end.

应用
应用	Active, N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end. For use in Kinase Assays.
主要应用	Kinase Assay

生物信息
来源	Expressed in E. coli
品种	Human
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	NM_002758.3
Entrez基因汇总	This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
基因符号	MKK6 MAP2K6 PRKMK6 MEK6 SAPKK3 MAPKK6
蛋白靶	MKK6
纯化方法	Amylose resin beads
靶子系列	STE
UniProt编号	P52564
UniProt汇总	FUNCTION: SwissProt: P52564 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively. SIZE: 334 amino acids; 37492 Da SUBUNIT: Interacts with Yersinia yopJ. TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas. PTM: Weakly autophosphorylated. & Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway. SIMILARITY: SwissProt: P52564 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.

产品使用声明
质量保证	Routinely evaluated by phosphorylation of unactive p38α/SAPK2a.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -70°C

包装信息
数量	250 µg
包装	Also available in 10 μg size (cat#14-303) and in bulk (cat# 14-303-K).

merck millipore,默克密理博,14-303M,MKK6/SKK3 Protein, active, 250 µg

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