merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB3070,Anti-Granzyme B Antibody, clone GrB-7

  • merck millipore,默克密理博,MAB3070,Anti-Granzyme B Antibody, clone GrB-7

    产品名称：Anti-Granzyme B Antibody, clone GrB-7
    产品型号：MAB3070
    Detect Granzyme B using this Anti-Granzyme B Antibody, clone GrB-7 validated for use in WB, IH(P).

    merck millipore,默克密理博,MAB3070,Anti-Granzyme B Antibody, clone GrB-7

  • 产品介绍
  • merck millipore,默克密理博,MAB3070,Anti-Granzyme B Antibody, clone GrB-7

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMCulture SupernatantMonoclonal Antibody
    描述
    产品目录编号 MAB3070
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Granzyme B Antibody, clone GrB-7
    产品信息
    格式 Culture Supernatant
    演示 Liquid
    应用
    应用 Detect Granzyme B using this Anti-Granzyme B Antibody, clone GrB-7 validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Immunoblotting

    Immunohistochemistry of granzyme B-expressing lymphocytes in sublimate sections and formalin-fixed paraffin-embedded tissues (1:20 dilution). Does not react with other cell types. Cannot be used on frozen sections.

    Note on the use of MAB3070 on paraffin sections:

    Tissue slides should be pretreated with an antigen retrieval method, such as treatment with 0.1M sodium citrate for 10 min at 100°C. A working dilution of 1:20 is advised, but optimal working dilutions must be determined by end user.
    生物信息
    克隆 GrB-7
    宿主 Mouse
    特异性 Monoclonal antibody recognizes the 33 kDa granzyme B.

    Reacts specifically with human serine protease granzyme B. Does not cross-react with human granzyme A. Granzyme B localizes in cytoplasmic granules and can be used as a marker for NK cells and activated cytotoxic T-cells.
    同种型 IgG2a
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_004131.3
    Entrez基因汇总 Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
    基因符号
    • EC 3.4.21.79
    • GZMB
    • GRB
    • CGL-1
    • CCPI
    • CSP-B
    • C11
    • CTLA1
    • CTLA-1
    • Granzyme-2
    • CSPB
    • SECT
    • Fragmentin-2
    • CGL1
    • HLP
    • CTSGL1
    UniProt编号
    • P10144
    UniProt汇总 FUNCTION: SwissProt: P10144 # This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
    SIZE: 247 amino acids; 27688 Da
    SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
    SIMILARITY: SwissProt: P10144 ## Belongs to the peptidase S1 family. Granzyme subfamily. & Contains 1 peptidase S1 domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C for up to 12 months.
    包装信息
    数量 250 µL

    merck millipore,默克密理博,MAB3070,Anti-Granzyme B Antibody, clone GrB-7

上一件merck millipore产品：merck millipore,默克密理博,ABN326,Anti-CAPS-2 Antibody
下一件merck millipore产品：merck millipore,默克密理博,488230,Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem


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