merck millipore,默克密理愽
  • merck millipore,默克密理博,178497,Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

  • merck millipore,默克密理博,178497,Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

    产品名称：Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem
    产品型号：178497
    The Apoptosis Activator VII, Apoptozole, also referenced under CAS 1054543-47-3, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,178497,Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,178497,Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₃H₂₄F₆N₃O₃1054543-47-3
    描述
    概述 A cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 µM).
    产品目录编号 178497
    品牌系列 Calbiochem®
    同义词 N-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III
    参考
    参考 Cho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
    Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
    产品信息
    CAS号 1054543-47-3
    形式 White solid
    Hill配方 C₃₃H₂₄F₆N₃O₃
    化学配方 C₃₃H₂₄F₆N₃O₃
    Molar Mass 625.6
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,178497,Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

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