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描述 产品目录编号 CC1062 Replaces CC1063 品牌系列 Chemicon®
商名 - Chemicon
描述 TIMP-1, recombinant, active human 概述 Human TIMP-1, isolated from CHO cells transfected with human TIMP-1 cDNA. A single band at 29kDa is noted by SDS-PAGE. 产品信息 演示 Purified protein in 10 mM Sodium Phosphate, pH 7.3, 0.15M NaCl. 应用 主要应用 - Inhibits Activity/Function
生物信息 浓缩 varies by lot 品种 Human 特异活性 BIOLOGICAL ACTIVITY: <br /><br />IC50=1.38 x 10E-9M (versus 6.7 x 10E-9 M MMP-1). [Nagai, Y, (1984) Jpn. Jp. Inflam. 4:123-130] Entrez基因编号 - NM_003254.2
Entrez基因汇总 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. 基因符号 - HCI
- TIMP1
- TIMP
- FLJ90373
- CLGI
- EPA
- EPO
- TIMP-1
UniProt编号 - P01033
UniProt汇总 FUNCTION: SwissProt: P01033 # Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
SIZE: 207 amino acids; 23171 Da
SUBCELLULAR LOCATION: Secreted.
PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds.
SIMILARITY: SwissProt: P01033 ## Belongs to the protease inhibitor I35 (TIMP) family. & Contains 1 NTR domain.产品使用声明 销售限制 This product is not available for sale in Japan. 使用声明 - Manufactured by Daiichi Fine Chemical Co., Ltd
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 5 µg 包装 5 μg/vial
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