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merck millipore,默克密理博,MAB2637,Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1
产品名称：Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1
产品型号：MAB2637
Detect Integrin beta-3 (CD61) using this Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 validated for use in FC, IH.
merck millipore,默克密理博,MAB2637,Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M IHC, FC AHm Purified Monoclonal Antibody 描述 产品目录编号 MAB2637 描述 Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 Alternate Names - GPIIIa
- CD61 antigen
- Platelet membrane glycoprotein IIIa
- integrin beta chain, beta 3
- integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
- platelet glycoprotein IIIa
背景信息 The integrin family of cell adhesion receptors consists of several membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor. The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented.
Platelet membrane glycoprotein Integrin beta3 or CD61 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets.产品信息 格式 Purified 控制 - Mouse bone marrow-derived cells
演示 Purified armenian hamster monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Integrin beta-3 (CD61) using this Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 validated for use in FC, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Piali, 1995). 生物信息 免疫原品种 Recombinant protein corresponding to mouse Integrin beta-3. 表位 Unknown 克隆 HMb3-1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Armenian Hamster 特异性 The antibody recognizes Integrin beta-3. 同种型 IgG 品种反应性 Mouse Species Reactivity Note Demonstrated to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_058060.2
基因符号 - GPIIIa
- CD61
- GP3A
纯化方法 Protein G purfied UniProt编号 - O54890
UniProt汇总 FUNCTION: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-3 associates with either alpha-IIB or alpha-V. Interacts with FLNB and COMP (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling (By similarity).
SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.
Contains 1 VWFA domain.产品使用声明 质量保证 Evaluated by Flow Cytometry on mouse bone marrow-derived cells.
Flow Cytometry Analysis: 0.1-1 µg/mL of the antibody detected Integrin beta-3 on mouse bone marrow-derived cells使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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