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品种反应性 主要应用 宿主 格式 抗体类型 Ch, H, M, R, Po IHC, ICC M Cy3 Monoclonal Antibody 描述 产品目录编号 MAB3402C3 描述 Anti-GFAP Antibody, Cy3 Conjugate Alternate Names - GFAP
- Glial fibrillary acidic protein
背景信息 Glial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system. 产品信息 格式 Cy3 控制 - Differentiated ReNcell VMs
演示 Purified mouse monoclonal IgG1 conjugated to Cy3 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Anti-GFAP Antibody, Cy3 Conjugate is an antibody against GFAP for use in IC, IH. 主要应用 - Immunohistochemistry
- Immunocytochemistry
应用说明 Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected GFAP in adult mouse brain tissue. 生物信息 免疫原品种 Purified glial filament protein (Debus, E., 1983). 宿主 Mouse 特异性 The antibody reacts with mouse GFAP. In tissue sections this
antibody stains astrocytes and Bergman glia cells (Debus, E., 1983).同种型 IgG1 品种反应性 ChickenHumanMouseRatPig Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human, Rat, Porcine, and Chicken based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002046
Entrez基因汇总 This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]. 基因符号 - GFAP
纯化方法 Protein A purified UniProt编号 - P14136
UniProt汇总 FUNCTION: GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
SIZE: 432 amino acids; 49880 Da
SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
DISEASE: Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
SIMILARITY: Belongs to the intermediate filament family.产品使用声明 质量保证 Evaluated by Immunocytochemistry in differentiated ReNcell VMs.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected GFAP in differentiated ReNcell VMs.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
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