merck millipore,默克密理愽
  • merck millipore,默克密理博,05-1106,Anti-IGF-IR Antibody, β-subunit, clone 1-2

  • merck millipore,默克密理博,05-1106,Anti-IGF-IR Antibody, β-subunit, clone 1-2

    产品名称：Anti-IGF-IR Antibody, β-subunit, clone 1-2
    产品型号：05-1106
    Anti-IGF-IR Antibody, β-subunit, clone 1-2 is an antibody against IGF-IR for use in WB, IH(P).

    merck millipore,默克密理博,05-1106,Anti-IGF-IR Antibody, β-subunit, clone 1-2

  • 产品介绍
  • merck millipore,默克密理博,05-1106,Anti-IGF-IR Antibody, β-subunit, clone 1-2

    Replacement Information
    Replacement Information 05-1106 is a recommended replacement for MAB1123

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, H, RWBMAffinity PurifiedMonoclonal Antibody
    描述
    产品目录编号 05-1106
    Replaces MAB1123
    描述 Anti-IGF-IR Antibody, β-subunit, clone 1-2
    背景信息 IGF-I and -II signal through the IGF-I Receptor, which is homologous to the Insulin Receptor. The high-affinity IGF-II Receptor does not play a direct role in signaling, but regulates the concentration of free IGF-II. The IGFs are involved in skeletal growth, and are essential for prevention of apoptosis. Serum levels of free IGFs are kept low by the action of IGF binding proteins (IGFBPs), which sequester the IGFs. Overexpression of IGFBPs may induce apoptosis, presumably by reduction of free IGF; IGFBP levels are also altered in some cancers. The IGF-I Receptor is not as mitogenic as some other growth factor receptors, but its ability to activate the PI3 Kinase pathway, through the Insulin Receptor Substrate (IRS) proteins, is critical for mediating cell survival.
    产品信息
    格式 Affinity Purified
    控制
    • C2C12 Cell Lysate
    演示 Purified mouse monoclonal IgG2b in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
    应用
    应用 Anti-IGF-IR Antibody, β-subunit, clone 1-2 is an antibody against IGF-IR for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry(paraffin): Representative images from a previous lot.
    Optimal Staining of IGF Monoclonal Antibody: Placenta

    Western Blot: A previous lot of this antibody was used at 1-2 µg/mL for 2 hours at room temperature.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 A 15-mer peptide corresponding to a.a. 1323-1337 (Tyr-RKNERALPLPQSSTC) from the C-terminal of β-subunit of human IGF-1R.
    表位 Between a.a. 1323-1337 of IGF-1R
    克隆 1-2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes the β-subunit of type I Insulin-like Growth Factor Receptor (IGF-1R). It shows no cross-reaction with insulin receptor. Its epitope localizes between a.a. 1323-1337 of IGF-1R. Both IGF-1R and insulin receptor are synthesized as a single polypeptide which is glycosylated and proteolytically cleaved to give the α- and β-subunits, which are disulfide-linked in a β-α-α-β configuration in the mature receptor. The α-subunit is completely extracellular, while the β-subunit spans membrane.
    同种型 IgG2b
    品种反应性 MouseHumanRat
    Species Reactivity Note Mouse and rat. Expected to react with human based on sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000875.3
    Entrez基因汇总 This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq]

    基因符号
    • CD221
    • IGF1R
    • MGC142170
    • MGC18216
    • IGFIR
    • JTK13
    • MGC142172
    纯化方法 Affinity Purfied
    UniProt编号
    • P08069
    UniProt汇总 FUNCTION: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.
    CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
    ENZYME REGULATION: Autophosphorylation activates the kinase activity.
    SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Expressed in a variety of tissues.
    PTM: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).
    PTM: Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.
    DISEASE: Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.
    SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    SIMILARITY: Contains 3 fibronectin type-III domains.
    SIMILARITY: Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on C2C12 lysates.

    Western Blot Analysis: 1:500 dilution of this lot detected IGF-1 Receptor beta on 10 μg of C2C12 lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable at 2-8°C in undiluted aliquots for up to 1 year from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-1106,Anti-IGF-IR Antibody, β-subunit, clone 1-2

上一件merck millipore产品：merck millipore,默克密理博,PMEF-CFL-P1,EmbryoMax Primary Mouse Embryo Fibroblasts, Not Mytomycin C Treated, Strain CF1, passage 1
下一件merck millipore产品：merck millipore,默克密理博,2402,Stat-Matic II Plate Washer, with bottle


相关产品

merck millipore,默克密理博,AB15190,Anti-Neurofascin 186 Antibody merck millipore,默克密理博,AB15190,Anti-Neurofascin 186 Antibody

merck millipore,默克密理博,07-2192,Anti-phospho-TBK1 (Ser172) Antibody merck millipore,默克密理博,07-2192,Anti-phospho-TBK1 (Ser172) Antibody

merck millipore,默克密理博,14-693,PTK5 Protein, active, 10 µg merck millipore,默克密理博,14-693,PTK5 Protein, active, 10 µg

merck millipore,默克密理博,UFC510096,Amicon Ultra-0.5 Centrifugal Filter Unit with Ultracel-100 membrane merck millipore,默克密理博,UFC510096,Amicon Ultra-0.5 Centrifugal Filter Unit with Ultracel-100 membrane

merck millipore,默克密理博,PMEF-CFL-P1,EmbryoMax Primary Mouse Embryo Fibroblasts, Not Mytomycin C Treated, Strain CF1, passage 1 merck millipore,默克密理博,PMEF-CFL-P1,EmbryoMax Primary Mouse Embryo Fibroblasts, Not Mytomycin C Treated, ...

merck millipore,默克密理博,2402,Stat-Matic II Plate Washer, with bottle merck millipore,默克密理博,2402,Stat-Matic II Plate Washer, with bottle

merck millipore,默克密理博,286888,BHQ - CAS 88-58-4 - Calbiochem merck millipore,默克密理博,286888,BHQ - CAS 88-58-4 - Calbiochem

merck millipore,默克密理博,07-1231,Anti-Notch1 Antibody, Intracellular merck millipore,默克密理博,07-1231,Anti-Notch1 Antibody, Intracellular

merck millipore,默克密理博,MAB2637,Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1 merck millipore,默克密理博,MAB2637,Anti-Integrin beta-3 (CD61) Antibody, clone HMb3-1

merck millipore,默克密理博,CBL497,Anti-CD49e Antibody, clone SAM-1 merck millipore,默克密理博,CBL497,Anti-CD49e Antibody, clone SAM-1


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部