merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB2259,Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7

  • merck millipore,默克密理博,MAB2259,Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7

    产品名称：Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7
    产品型号：MAB2259
    Detect Cholesterol-24 Hydroxylase using this Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7 validated for use in WB, IP, IC, IH.

    merck millipore,默克密理博,MAB2259,Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7

  • 产品介绍
  • merck millipore,默克密理博,MAB2259,Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Rb, M, H, RIHC, WB, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB2259
    描述 Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7
    Alternate Names
    • cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
    • Cytochrome P450 46A1
    • cholesterol 24-hydroxylase
    • cytochrome P450, family 46
    • cytochrome P450, family 46, subfamily A, polypeptide 1
    背景信息 In enzymology, a cholesterol 24-hydroxylase (EC 1.14.13.98) is an enzyme that catalyzes the chemical reaction:
    cholesterol + NADPH + H+ + O2 --> (24S)-24-hydroxycholesterol + NADP+ + H2O. Cholesterol 24-hydroxylase, a cytochrome P450 (CYP46A1), is expressed at 100-fold higher levels in the brain than in the liver. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. Studies indicate that cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain (Lund, 2003).
    产品信息
    格式 Purified
    控制
    • Mouse brain lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
    应用
    应用 Detect Cholesterol-24 Hydroxylase using this Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7 validated for use in WB, IP, IC, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    • Immunocytochemistry
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to human cholesterol-24 hydroxylase.
    表位 unknown
    克隆 1A7
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes cholesterol-24 hydroxylase.
    同种型 IgG1κ
    品种反应性 RabbitMouseHumanRat
    Species Reactivity Note Demonstrated to react with mouse. Predicted to react with human, rat, and rabbit based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_006659
    Entrez基因汇总 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq].
    基因符号
    • CYP46A1
    • CH24H
    • CP46
    • CYP46
    纯化方法 Protein G purfied
    UniProt编号
    • Q9Y6A2
    UniProt汇总 FUNCTION: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.

    CATALYTIC ACTIVITY: Cholesterol + NADPH + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O.

    COFACTOR: Heme group By similarity.

    SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

    TISSUE SPECIFICTY: Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.

    SEQUENCE SIMILARITIES: Belongs to the cytochrome P450 family.

    BIOPHYSICOCHEMICAL PROPERTIEIS: Kinetic parameters:

    KM=2.2 µM for 24(S)-hydroxycholesterol
    产品使用声明
    质量保证 Evaluated by Western Blot in Cholesterol-24 hydroxylase mouse brain lysate.

    Western Blot Analysis: 1 µg/ml of this antibody detected Cholesterol-24 hydroxylase on 10 µg of Cholesterol-24 hydroxylase mouse brain lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB2259,Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7

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