merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB19562X,Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated

  • merck millipore,默克密理博,MAB19562X,Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated

    产品名称：Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated
    产品型号：MAB19562X
    This Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated is validated for use in FC, IC for the detection of Laminin-5.

    merck millipore,默克密理博,MAB19562X,Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated

  • 产品介绍
  • merck millipore,默克密理博,MAB19562X,Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, FCMAlexaFluor®488Monoclonal Antibody
    描述
    产品目录编号 MAB19562X
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor® 488 conjugated
    背景信息 Laminins are basement membrane, extracellular matrix glycoproteins that are composed of alpha, beta and gamma heterotrimeric chains. Different combinations of five alpha chains, three beta chains, and two gamma chains form at least 12 laminin isoforms. Laminin-5 (LN5), which consists of laminin alpha3, beta3 and gamma2 chains, is a highly conserved component of anchoring filaments underlying the hemidesmosome structure of epidermal keratinocytes. Mutations or deletion in the LN5 genes (LAMA3, LAMB3, and LAMC2) is associated with epidermolysis bullosa, a lethal skin blistering disease. LN5 may stabilize the epidermal/dermal junction of skin through binding with integrins alpha3/beta1, alpha6/beta4 and type VII collagen and has a critical role in the anchorage and locomotion of a wide variety of cell types, including epithelial cells, fibroblasts, neurons and leukocytes. Compared to fibronectin, collagen, or vitronectin, cells of epithelial origin will adhere to Laminin-5 faster and will spread to a larger extent. Recently, Laminin-5 is attracting attention as a substrate for carcinoma cells that may stimulate migration, since it has been detected at the leading edge of invasive cancer tissue in several types of human carcinomas (Niki, et al., 2002, Lohi, et al., 2001).
    产品信息
    格式 AlexaFluor®488
    演示 Purified immunoglobulin conjugated to Alexa Fluor® 488. Liquid in PBS containing 1% BSA, 0.05% Tween®-20 and 0.05% sodium azide.
    应用
    应用 This Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated is validated for use in FC, IC for the detection of Laminin-5.
    主要应用
    • Immunocytochemistry
    • Flow Cytometry
    应用说明 Immunocytochemistry: 2 μg/mL
    Flow cytometry
    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Amino acid residues 382-608 of human laminin gamma2 chain (III domain) expressed as a GST fusion protein.
    表位 amino acids 382-608
    克隆 clone D4B5
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Monoclonal antibody MAB19562 was developed against amino acid residues 382-608 of human laminin gamma2 chain (III domain) expressed as a GST fusion protein. The antibody recognizes the 150 kDa (precursor form) and 105 kDa (mature form) chain proteins of Laminin-5. No reactivity is expected with other laminin types, as the gamma2 chain of laminin is unique to laminin-5.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_018891.2
    • NM_005562.2
    基因符号
    • CSF
    • LAMC2
    • EBR2
    • LAMB2T
    • MGC141938
    • MGC138491
    • LAMNB2
    • epiligrin
    • BM600-100kDa
    • BM600
    • kalinin-105kDa
    • nicein-100kDa
    • EBR2A
    • B2T
    UniProt编号
    • Q13753
    UniProt汇总 FUNCTION: SwissProt: Q13753 # Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
    SIZE: 1193 amino acids; 130976 Da
    SUBUNIT: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-2 is a subunit of laminin-5 (epiligrin/kalinin/nicein).
    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
    TISSUE SPECIFICITY: The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.DOMAIN:SwissProt: Q13753 The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. & Domain IV is globular.
    DISEASE: SwissProt: Q13753 # Defects in LAMC2 are a cause of junctional epidermolysis bullosa gravis (JEB) [MIM:226700]; also known as junctional epidermolysis bullosa Herlitz-Pearson type. JEB is a blistering disorder in skin that is characterized by a separation of basal cells from the basement membrane due to a decreased number of hemidesmosomes. Laminin-5 is missing from the basement membrane of patients with the gravis form of epidermolysis bullosa.
    SIMILARITY: Contains 8 laminin EGF-like domains. & Contains 1 laminin IV type A domain.
    MISCELLANEOUS: Binds heparin (By similarity).
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.
    储存和货运信息
    存储条件 Maintain at 2°-8°C for up to 12 months from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB19562X,Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor 488 conjugated

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