merck millipore,默克密理博,124034,Akt Inhibitor XV, Isozyme-Selective

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Merck Millipore 默克密理愽

merck millipore,默克密理博,124034,Akt Inhibitor XV, Isozyme-Selective - Calbiochem

经验配方
C₃₃H₂₉N₇O

描述
概述	A cell-permeable naphthyridinone compound that acts as an allosteric Akt1/2-selective inhibitor (IC₅₀ = 3.5, 42, and 1900 nM against Akt1, Akt2, and Akt3, respectively) in a PH domain-dependent, but not ATP-competitive, manner, with little activity against a panel of more than 160 other kinases, including the related AGC family kinases (inactive at 10 µM against GSK, PDK1, PKA, PKC, and SGK). Effectively inhibits the basal Akt phosphorylation in cancer cells with deregulated Akt pathway activation, including the HCT116 colorectal carcinoma and a panel of breast cancer cell lines (IC₅₀ <500 nM), and suppresses Akt-dependent cell growth both in cultures in vitro (IC₅₀ ≤1 µM) and in mice in vivo (50 to 100 mg/kg, SC). Although also referred to as AKTi-1/2, this is not the same compound as Akt Inhibitor XV (Cat. Nos. 124017 & 124018).
产品目录编号	124034
品牌系列	Calbiochem®
同义词	5-Hydroxy-3-phenyl-2-(4-((4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperdin-1-yl)methyl)phenyl)-1,6-naphthyridine

参考
参考	She, Q.B., et al. 2010. Cancer Cell 18, 39. Bilodeau, M.T., et al. 2008. Bioorg. Med. Chem. Lett. 18, 3178. She, Q.B, et al. 2008. PLoS One 3, e3065.

生物信息
纯度	≥97% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

merck millipore,默克密理博,124034,Akt Inhibitor XV, Isozyme-Selective - Calbiochem

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