merck millipore,默克密理愽
  • merck millipore,默克密理博,04-856,Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal

  • merck millipore,默克密理博,04-856,Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal

    产品名称：Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal
    产品型号：04-856
    Detect TBK1 using this Anti-TBK1 Antibody, clone AOW9 validated for use in WB & IP.

    merck millipore,默克密理博,04-856,Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-856,Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Ch, H, M, CaWBRbCulture SupernatantMonoclonal Antibody
    描述
    产品目录编号 04-856
    Replaces 05-856
    描述 Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal
    Alternate Names
    • TANK-binding kinase 1
    • NF-kB-activating kinase
    • NF-kappa-B-activating kinase
    背景信息 TBK, also known as IκB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-κB) activation. The NF-κB complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-κB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-κB inhibition caused by TANK.
    产品信息
    格式 Culture Supernatant
    控制
    • RIPA lysates from HEK293 cells.
    演示 Cultured supernatant containing 0.05% sodium azide.
    应用
    应用 Detect TBK1 using this Anti-TBK1 Antibody, clone AOW9 validated for use in WB & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation:
    1-4 μL of a previous lot immunoprecipitated TBK1 from 100 μg of HEK293 RIPA lysate.
    生物信息
    免疫原品种 Peptide corresponding to the sequence C...EEVS... (amino acids 642-645) of human TANK-binding kinase 1 (TBK1) with an N-terminal cysteine added for conjugation purposes.
    表位 a.a. 642-645
    克隆 AOW9
    宿主 Rabbit
    特异性 TBK1; Does not cross-react with IKKε, IKKα or IKKβ.
    同种型 IgG
    品种反应性 ChickenHumanMouseCanine
    Species Reactivity Note Human. Predicted to cross-react with mouse, dog, and chicken based on sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_037386
    Entrez基因汇总 The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq]
    基因符号
    • T2K
    • EC 2.7.11.1
    • FLJ11330
    • NAK
    UniProt编号
    • Q9UHD2
    UniProt汇总 FUNCTION: Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. Ref.1 Ref.2 Ref.5 Ref.7 Ref.8 Ref.11

    Catalytic activity ATP + a protein = ADP + a phosphoprotein.

    SUBUNIT: Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between TBK1 and SIKE. Interacts with HCV NS3, a hepatitis C virus protein and with BDV P protein, a Borna disease virus protein. Ref.1 Ref.6 Ref.9 Ref.10 Ref.12 Ref.13 Ref.14

    SUBCELLULAR LOCATION:Cytoplasm. Ref.11

    SPECIFICITY:Ubiquitous with higher expression in testis. Ref.2

    SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by western blot on RIPA lysates from HEK293 cells.

    Western Blot Analysis:
    A 1:500 to 1:2,000 of this antibody detected TBK1 in RIPA lysates from HEK293 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-856,Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal

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下一件merck millipore产品：merck millipore,默克密理博,MAB4327,Anti-Axin-1 Antibody, clone 3F4.2


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