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merck millipore,默克密理博,513028,PD 166285 - CAS 212391-63-4 - Calbiochem
产品名称：PD 166285 - CAS 212391-63-4 - Calbiochem
产品型号：513028
A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor that suppresses angiogenesis both in vitro and in vivo.
merck millipore,默克密理博,513028,PD 166285 - CAS 212391-63-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₆H₂₇Cl₂N₅O₂ • 2HCl 212391-63-4 描述 概述 A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor (IC50 against against c-Src, Wee1, FGFR-1, Myt1, EGFR, and PDGFRβ = 8.4, 24, 39.3, 72, 87.5 and 98.3 nM, respectively) that suppresses angiogenesis both in vitro (max inhibition dose at 100 nM in HUVEC microcapillary formation assays) and in vivo (max inhibition achieved via 5 mg/kg p.o. in murine Matrigel plug angiogenesis assays), while exhibiting much reduced potency against Chk1, MAPK, and PKC (IC50 = 3.4, 5, and 22.7 µM, respectively) and little activity toward IRTK and Cdk4/D1 even at concentrations as high as 50 µM. Shown to effectively block PDGF-, EGF-, and bFGF-stimulated receptor phosphorylations (IC50 = 6.5, 1600, and 97.3 nM, respectively) and other cellular responses in rat aortic smooth muscle cells. Inhibition of cellular Wee1 activity by 500 nM PD 166285 in combination with 50 ng/ml nocodazole (Cat. No. 487928) treatment is also reported to result in a blockage of radiation-induced Cdc2 phosphorylation on Tyr15 and Thr14 in 7 human cancer cells and specifically demonstrated to sensatize PA-1 cultures to radiation-induced cell death in a p53-dependent manner. 产品目录编号 513028 品牌系列 Calbiochem®
同义词 6-(2,6-Dichlorophenyl)-2-(4-(2-(diethylaminoethoxy)-phenylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 2HCl, PD166285, PD0166285, PDGFR Tyrosine Kinase Inhibitor XIX, Wee1 Inhibitor IV 参考 参考 Wang, Y., et al. 2001. Cancer Res. 61, 8211.
Dimitroff, C.J., et al. 1999. Invest. New Drugs 17, 121.
Roginskaya, V., et al. 1999. Leukemia 13, 855.
Panek, R.L., et al. 1997. J. Pharmacol. Exp. Ther. 283, 1433.产品信息 CAS号 212391-63-4 形式 Pale yellow solid Hill配方 C₂₆H₂₇Cl₂N₅O₂ • 2HCl 化学配方 C₂₆H₂₇Cl₂N₅O₂ • 2HCl Molar Mass 585.4 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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