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merck millipore,默克密理博,MAB1587,Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2
产品名称：Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2
产品型号：MAB1587
Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 is an antibody against Glutamate Transporter for use in IH & WB.
merck millipore,默克密理博,MAB1587,Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB, IHC M Purified Monoclonal Antibody 描述 产品目录编号 MAB1587 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 Alternate Names - EAAT3
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide. 应用 应用 Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 is an antibody against Glutamate Transporter for use in IH & WB. 主要应用 - Western Blotting
- Immunohistochemistry
应用说明 Western blot: 1-2 μg/mL
Immunohistochemistry: 1-2 μg/mL
Optimal working dilutions must be determined by end user.
EAAC1 is approximately 66-70kDa; the protein can form homomultimers during preparation as well, thus often times large 200-220kDa bands can also be seen.生物信息 免疫原品种 C-terminus peptide (KDKSDTISFTQTSQF) (Catalog Number AG372). 克隆 4D6.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Glutamate Transporter EAAC1.
Based on protein sequence the antibody is expected to react with mouse, bovine and rabbit.同种型 IgG1 品种反应性 Rat 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004170.4
基因符号 - EAAT3
- SLC1A1
- EAAC1
UniProt编号 - P43005
UniProt汇总 FUNCTION: SwissProt: P43005 # Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
SIZE: 524 amino acids; 57100 Da
SUBUNIT: Interacts with ARL6IP5/PRAF3 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
PTM: Glycosylated.
DISEASE: SwissProt: P43005 # Defects in SLC1A1 may be a cause of dicarboxylicamino aciduria [MIM:222730]; also known as glutamate-aspartate transport defect. This is as defect in renal and probably intestinal transport of glutamic and aspartic acids and is associated with moderate hyperprolinemia.
SIMILARITY: SwissProt: P43005 ## Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to six months. 包装信息 数量 100 µg
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