merck millipore,默克密理博,FCMAB335PE,Milli-Mark™ Anti-Vesicular Glutamate Transporter 1-PE Antibody, clone 3C10.2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R	FC	M	Phycoerythrin	Monoclonal Antibody

描述
产品目录编号	FCMAB335PE
商名	Milli-Mark
描述	Milli-Mark™ Anti-Vesicular Glutamate Transporter 1-PE Antibody, clone 3C10.2
Alternate Names	Brain-specific Na(+)-dependent inorganic phosphate cotransporter VGluT1 Solute carrier family 17 member 7
背景信息	VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate. Vesicular glutamate transporters pack the neurotransmitter into synaptic vesicles so that they can be released into the synapse. VGLUTs are dependent on a proton gradient that they create by hydrolysing adenosine triphosphate (ATP). VGLUTs have only between one hundredth and one thousandth the affinity for glutamate that EAATs have.

产品信息
格式	Phycoerythrin
控制	B35 cells
演示	Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Detect Vesicular Glutamate Transporter 1 using this Milli-Mark Anti-Vesicular Glutamate Transporter 1-PE Antibody, clone 3C10.2 validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Recombinant protein from rat Vesicular Glutamate Transporter-1
克隆	3C10.2
宿主	Mouse
特异性	Antibody recognizes VGLUT-1.
同种型	IgG1
品种反应性	Rat
Species Reactivity Note	Tested and passed on Rat.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_446311
Entrez基因汇总	A Na(+)-dependent inorganic phosphate cotransporter.
基因符号	Slc17a7 Bnpi Vglut1
纯化方法	Protein A Purified
UniProt编号	Q62634
UniProt汇总	FUNCTION: SwissProt: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. SIZE: 560 amino acids; 61665 Da [MW of unprocessed precursor] SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein (Potential). Cell junction, synapse, synaptosome. TISSUE SPECIFICITY: Expressed in the cerebellum, cerberal cortex and hippocampus. Isoform 2 is expressed specifically in retina. SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

产品使用声明
质量保证	Evaluated by flow cytometry using B35 cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB335PE,Milli-Mark™ Anti-Vesicular Glutamate Transporter 1-PE Antibody, clone 3C10.2

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