merck millipore,默克密理愽
  • merck millipore,默克密理博,17-294,Rho Activation Assay Kit

  • merck millipore,默克密理博,17-294,Rho Activation Assay Kit

    产品名称：Rho Activation Assay Kit
    产品型号：17-294
    PP1/PP2A Toolbox for the selective in vitro dephosphorylation of proteins.

    merck millipore,默克密理博,17-294,Rho Activation Assay Kit

  • 产品介绍
  • merck millipore,默克密理博,17-294,Rho Activation Assay Kit

    重要规格表

    主要应用 检测方法
    ABAColorimetric, Fluorescent, Chemiluminescence
    描述
    产品目录编号 17-294
    品牌系列 Upstate
    商名
    • Upstate
    描述 Rho Activation Assay Kit
    概述 A GST-tagged fusion protein, corresponding to residues 7-89 of mouse Rhotekin Rho Binding Domain, expressed in E. coli. Provided bound to glutathione-agarose. Purity >90%.
    产品信息
    部件
    • Rho Assay Reagent (Rhotekin RBD, agarose) (Cat.# 14-383)
    • 100X GTPγS, 10mM (Cat.# 20-176)
    • 100X GDP, 100mM (Cat.# 20-177)
    • Mg2+ Lysis/Wash Buffer, 5X (Cat.# 20-168)
    • Anti-Rho (-A, -B, -C), clone 55 (Cat.# 05-778)
    检测方法 ColorimetricFluorescentChemiluminescence
    应用
    应用 PP1/PP2A Toolbox for the selective in vitro dephosphorylation of proteins.
    主要应用
    • Affinity Binding Assay
    生物信息
    Entrez基因编号
    • NM_001664.2
    Entrez基因汇总 This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
    基因符号
    • H12
    • RHOA
    • RHO12
    • Rho12
    • RhoA
    • ARHA
    • ARH12
    • RHOH12
    UniProt编号
    • P08134
    • P61586
    • P62745
    UniProt汇总 FUNCTION: SwissProt: P62745 # Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
    SIZE: 196 amino acids; 22123 Da
    SUBUNIT: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.
    SUBCELLULAR LOCATION: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Note=Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus.
    PTM: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
    SIMILARITY: SwissProt: P62745 ## Belongs to the small GTPase superfamily. Rho family.
    MISCELLANEOUS: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.
    产品使用声明
    质量保证 Routinely evaluated by precipitating GTP- Rho from 3T3/A31 cell lysates, subsequent detection by immunoblot analysis using anti-Rho (05-778).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 1 kit
    包装 Kit capacity: 30 assays

    merck millipore,默克密理博,17-294,Rho Activation Assay Kit

上一件merck millipore产品：merck millipore,默克密理博,MAB8051P-K,Mouse Anti-Adenovirus, clone 2/6 (1mg)
下一件merck millipore产品：merck millipore,默克密理博,ABC834,Anti-ZIP-6 Antibody


相关产品

merck millipore,默克密理博,ABN190,Anti-CEA cell adhesion molecule 16 (Ceacam16) Antibody merck millipore,默克密理博,ABN190,Anti-CEA cell adhesion molecule 16 (Ceacam16) Antibody

merck millipore,默克密理博,16-661X,Magna ChIP™ Protein A Magnetic Beads -Trial Size merck millipore,默克密理博,16-661X,Magna ChIP™ Protein A Magnetic Beads -Trial Size

merck millipore,默克密理博,14-554,EphB4 Protein, active, 10 µg merck millipore,默克密理博,14-554,EphB4 Protein, active, 10 µg

merck millipore,默克密理博,ABC292,Anti-CHMP2B Antibody merck millipore,默克密理博,ABC292,Anti-CHMP2B Antibody

merck millipore,默克密理博,MAB8051P-K,Mouse Anti-Adenovirus, clone 2/6 (1mg) merck millipore,默克密理博,MAB8051P-K,Mouse Anti-Adenovirus, clone 2/6 (1mg)

merck millipore,默克密理博,ABC834,Anti-ZIP-6 Antibody merck millipore,默克密理博,ABC834,Anti-ZIP-6 Antibody

merck millipore,默克密理博,MAB1587,Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 merck millipore,默克密理博,MAB1587,Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2

merck millipore,默克密理博,108543,乙醇 merck millipore,默克密理博,108543,乙醇

merck millipore,默克密理博,FCMAB335PE,Milli-Mark™ Anti-Vesicular Glutamate Transporter 1-PE Antibody, clone 3C10.2 merck millipore,默克密理博,FCMAB335PE,Milli-Mark™ Anti-Vesicular Glutamate Transporter 1-PE Antibody, clone ...

merck millipore,默克密理博,SF-1351,CASC5; Human, Cyanine 3 RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1351,CASC5; Human, Cyanine 3 RNA Detection Probe,SmartFlare


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部