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merck millipore,默克密理博,GF012,Monocyte Chemotactic Protein-1, Recombinant human
产品名称:Monocyte Chemotactic Protein-1, Recombinant human
产品型号:GF012
The human macrophage chemoattractant protein-1 (or MCP-1 protein) also called human macrophage/monocyte chemotactic & activating factor (MCAF) is an 8.6 kDA protein containing 76 amino acids residues.
merck millipore,默克密理博,GF012,Monocyte Chemotactic Protein-1, Recombinant human
- 产品介绍
重要规格表
主要应用 品种 来源 纯度 CULT Human E.coli Greater than 99% by SDS-PAGE and HPLC analysis 描述 产品目录编号 GF012 品牌系列 Chemicon®
商名 - Chemicon
描述 Monocyte Chemotactic Protein-1, Recombinant human 概述 Human macrophage chemoattractant protein-1 (MCP-1) also called human macrophage/monocyte chemotactic and activating factor (MCAF) is an 8.6 kDA protein containing 76 amino acids residues. It plays an important role in the inflammatory response of blood monocytes and tissue macrophages. Alternate Names - MCAF
- MCP-1
产品信息 演示 Lyophilized protein with no additives. 应用 应用 The human macrophage chemoattractant protein-1 (or MCP-1 protein) also called human macrophage/monocyte chemotactic & activating factor (MCAF) is an 8.6 kDA protein containing 76 amino acids residues. 主要应用 - Cell Culture
生物信息 纯度 Greater than 99% by SDS-PAGE and HPLC analysis 来源 E.coli 品种 Human 特异活性 The biological activity was determined by a chemotaxis assay using human monocytes. Significant chemotaxis response was found to be in the range of 10-100 ng/mL. Entrez基因编号 - NM_002982.3
Entrez基因汇总 This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. 基因符号 - MCP-1
- CCL2
- SMC-CF
- MCAF
- HSMCR30
- GDCF-2
- SCYA2
- MCP1
- HC11
- MGC9434
UniProt编号 - P13500
UniProt汇总 FUNCTION: SwissProt: P13500 # Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
SIZE: 99 amino acids; 11025 Da
SUBUNIT: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.
SUBCELLULAR LOCATION: Secreted.
PTM: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.
SIMILARITY: SwissProt: P13500 ## Belongs to the intercrine beta (chemokine CC) family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstitute in water to a concentration of 0.1 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted GF012 should be stored at -20°C in undiluted aliquots for up to six months. 包装信息 数量 20 µg
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