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merck millipore,默克密理博,07-981,Anti-Cbx7 Antibody
产品名称：Anti-Cbx7 Antibody
产品型号：07-981
Anti-Cbx7 Antibody is a Rabbit Polyclonal Antibody for detection of Chromobox protein homolog 7 (Cbx7) also known as hromobox protein homolog 7 & has been validated in WB & IP.
merck millipore,默克密理博,07-981,Anti-Cbx7 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-981 描述 Anti-Cbx7 Antibody Alternate Names - chromobox protein homolog 7
- chromobox homolog 7
背景信息 Chromobox protein homologue 7 (Cbx7) is a member of the mammalian chromobox family of proteins. As a component of the Polycomb repressive complex 1 (PRC1), Cbx7, is involved in the maintenance and prolongation of cultured epithelial cell lifespan, and has been shown to function independently of BMI-1 in the repression of INK4a/ARF, a known tumor suppressor locus. Cbx7 is also able to regulate cellular lifespan through maintaining CDKN2A repression. Studies have shown Cbx7 to be up-regulated in follicular lymphoma, suggesting potential as a human oncogene. 产品信息 格式 Affinity Purified 控制 - Mouse embryonic stem cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Cbx7 Antibody is a Rabbit Polyclonal Antibody for detection of Chromobox protein homolog 7 (Cbx7) also known as hromobox protein homolog 7 & has been validated in WB & IP. 主要应用 - Western Blotting
应用说明 Western Blot (Snap i.d.®) Analysis: 2 µg/mL from a representative lot detected Cbx7 on 10 µg of human and mouse embryonic stem cell lysates.
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP.生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of mouse Cbx7. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Cbx7 at the C-terminus. 品种反应性 Mouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_659060
基因符号 - Cbx7
- CBX7
纯化方法 Affinity purified UniProt编号 - Q8VDS3
UniProt汇总 FUNCTION: Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility (By similarity). Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
SUBUNIT STRUCTURE: Component of the chromatin-associated polycomb complex (PcG). Interacts with RING2 (By similarity). Interacts with RING1, but not with BMI1, EED or EZH2.
SUBCELLULAR LOCATION: Nucleus
DEVELOPMENTAL STAGE: In embryonic fibroblast cultured in vitro, expression gradually decreases with passage number and totally disappears in senescent cells.
SEQUENCE SIMILARITIES: Contains 1 chromo domain.产品使用声明 质量保证 Evaluated by Western Blot in mouse embryonic stem cell lysate.
Western Blot Analysis: 0.25 µg/mL of this antibody detected Cbx7 on 10 µg of mouse embryonic stem cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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