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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB1503 描述 Anti-Nogo A Antibody, clone 6A5.2 Alternate Names - reticulon 5
- Human NogoA
- My043 protein
- Neurite outgrowth inhibitor
- Neuroendocrine-specific protein
- Neuroendocrine-specific protein C homolog
- Nogo protein
- neurite growth inhibitor 220
- reticulon 4
背景信息 This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. 产品信息 格式 Purified 控制 - Rat brain lysate.
演示 Purified in PBS with 0.05% NaN3 应用 应用 Anti-Nogo A Antibody, clone 6A5.2 is an antibody against Nogo A for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant protein 表位 Unknown 克隆 6A5.2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Cat. # MAB1503 recognizes Nogo A. 同种型 IgM 品种反应性 RatHumanMouse Species Reactivity Note Mouse, Human and Rat. Reactivity with other species has not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_007008
Entrez基因汇总 This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq]
基因符号 - foocen
- ASY
- Foocen
- KIAA0886
- NI220/250
- NOGO
- NOGO-A
- NOGOC
- NSP
- NSP-CL
- Nbla00271
- Nbla10545
- Nogo-B
- Nogo-C
- RTN-X
- RTN-x
- RTN4-A
- RTN4-B1
- RTN4-B2
- RTN4-C
- Reticulon-5
纯化方法 Ammonium sulfate precipitation UniProt编号 - Q99P72
UniProt汇总 FUNCTION: Potent neurite growth inhibitor in vitro and plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. May inhibit BACE1 activity and amyloid precursor protein processing (By similarity).
SUBUNIT:Binds to RTN4R. Interacts with Bcl-xl and Bcl-2. Interacts in trans with CNTNAP1 (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains (By similarity).
ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named
isoforms=3; Name=1; IsoId=Q99P72-2; Sequence=Displayed; Name=2; IsoId=Q99P72-3; Sequence=VSP_018089, VSP_018090; Name=3; IsoId=Q99P72-1; Sequence=VSP_018088, VSP_018091.
DOMAIN:Three regions, residues 59-172, 544-725 and the loop 66
amino acids, between the two transmembrane domains, known as
Nogo-66 loop, appear to be responsible for the inhibitory effect on
neurite outgrowth and the spreading of neurons. This Nogo-66 loop, mediates also the binding of RTN4 to its receptor (By similarity).
SIMILARITY: Contains 1 reticulon domain.
SEQUENCE CAUTION: Sequence=BC056373;Type=Erroneous termination;Positions=721; Note=Translated as Glu.
产品使用声明 质量保证 Routinely tested on rat brain lysate
Lot Specific Tested Application 1: Western Blot
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. 包装信息 数量 100 µg
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