merck millipore,默克密理愽
  • merck millipore,默克密理博,05-704,Anti-ARNT1/HIF-1β Antibody, clone 4G9

  • merck millipore,默克密理博,05-704,Anti-ARNT1/HIF-1β Antibody, clone 4G9

    产品名称：Anti-ARNT1/HIF-1β Antibody, clone 4G9
    产品型号：05-704
    Detect ARNT1/HIF-1 beta with Anti-ARNT1/HIF-1β Antibody, clone 4G9 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.

    merck millipore,默克密理博,05-704,Anti-ARNT1/HIF-1β Antibody, clone 4G9

  • 产品介绍
  • merck millipore,默克密理博,05-704,Anti-ARNT1/HIF-1β Antibody, clone 4G9

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-704
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-ARNT1/HIF-1β Antibody, clone 4G9
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect ARNT1/HIF-1 beta with Anti-ARNT1/HIF-1β Antibody, clone 4G9 (Mouse Monoclonal Antibody), that has been shown to work in IP, WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 Protein A fusion protein corresponding to residues 399-777 of human aryl hydrocarbon receptor nuclear translocator (ARNT)
    克隆 clone 4G9
    宿主 Mouse
    特异性 ARNT
    同种型 IgG
    品种反应性 MouseHuman
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001668
    Entrez基因汇总 The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.
    基因符号
    • TANGO
    • ARNT
    • HIF-1beta
    • HIF1beta
    • HIF1B
    • HIF1BETA
    纯化方法 Protein G chromatography
    UniProt编号
    • P27540
    UniProt汇总 FUNCTION: SwissProt: P27540 # Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
    SIZE: 789 amino acids; 86636 Da
    SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, with HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7.
    SUBCELLULAR LOCATION: Nucleus.
    SIMILARITY: SwissProt: P27540 ## Contains 1 basic helix-loop-helix (bHLH) domain. & Contains 1 PAC (PAS-associated C-terminal) domain. & Contains 2 PAS (PER-ARNT-SIM) domains.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on lysates from HeLa, A431, 3T3/A31, or Jurkat cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-704,Anti-ARNT1/HIF-1β Antibody, clone 4G9

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