merck millipore,默克密理愽
  • merck millipore,默克密理博,05-859,Anti-Fibrinogen Antibody, clone GMA-035

  • merck millipore,默克密理博,05-859,Anti-Fibrinogen Antibody, clone GMA-035

    产品名称：Anti-Fibrinogen Antibody, clone GMA-035
    产品型号：05-859
    This Anti-Fibrinogen Antibody, clone GMA-035 is validated for use in ELISA, WB for the detection of Fibrinogen.

    merck millipore,默克密理博,05-859,Anti-Fibrinogen Antibody, clone GMA-035

  • 产品介绍
  • merck millipore,默克密理博,05-859,Anti-Fibrinogen Antibody, clone GMA-035

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-859
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Fibrinogen Antibody, clone GMA-035
    产品信息
    格式 Purified
    应用
    应用 This Anti-Fibrinogen Antibody, clone GMA-035 is validated for use in ELISA, WB for the detection of Fibrinogen.
    主要应用
    • Western Blotting
    • ELISA
    生物信息
    免疫原品种 Purified human fibrinogen
    宿主 Mouse
    特异性 fibrinogen
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_021871 / NM_005141 / NM_000509
    Entrez基因汇总 The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
    基因符号
    • MGC119425
    • FGA
    • MGC119423
    • Fib2
    • MGC119422
    纯化方法 DEAE purified
    UniProt编号
    • P02679
    • P02671
    • P02675
    UniProt汇总 FUNCTION: SwissProt: P02679 # Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    SIZE: 453 amino acids; 51512 Da
    SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).
    SUBCELLULAR LOCATION: Secreted.
    DOMAIN: SwissProt: P02679 A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
    PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon- (gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. & Sulfation of C-terminal tyrosines increases affinity for thrombin.DISEASE:SwissProt: P02679 # Defects in FGG are a cause of thrombophilia. & Defects in FGG are a cause of congenital afibrinogenemia [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.
    SIMILARITY: Contains 1 fibrinogen C-terminal domain.
    MISCELLANEOUS: The gamma-chain carries the main binding site for the platelet receptor.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on human fibrinogen
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 stable 2 years at -20°C from date of shipment
    包装信息
    数量 100 µg

    merck millipore,默克密理博,05-859,Anti-Fibrinogen Antibody, clone GMA-035

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