merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB1049,Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2

  • merck millipore,默克密理博,MAB1049,Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2

    产品名称：Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2
    产品型号：MAB1049
    Detect Bone Morphogenetic Protein 4 using this Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2 validated for use in ELISA, IC & WB.

    merck millipore,默克密理博,MAB1049,Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2

  • 产品介绍
  • merck millipore,默克密理博,MAB1049,Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, ELISA, ICCMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB1049
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2
    Alternate Names
    • DVR-4
    • BMP-4
    背景信息 Bone morphogenetic protein 4 (BMP4) is a polypeptide belonging to the TGF-β superfamily of proteins. It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb development and fracture repair. It has been shown to be involved in muscle development, bone mineralization, and uteric bud development. BMP4 has also been implicated in Fibrodysplasia Ossificans Progressiva in which it is underexpressed. In human embryonic development, BMP4 is a critical signalling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog (released from the ventral portion of the notochord) to establish a dorsal-ventral axis for the differentiation of later structures. BMP4 stimulates differentiation of overlying ectodermal tissue. Inhibition of the BMP4 signal (by chordin, noggin, or follistatin) causes the ectoderm to differentiate into the neural plate. If these cells also receive signals from FGF, they will differentiate into the spinal cord; in the absence of FGF the cells become brain tissue.
    产品信息
    格式 Purified
    控制
    • Mouse brain extract
    演示 Protein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
    应用
    应用 Detect Bone Morphogenetic Protein 4 using this Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2 validated for use in ELISA, IC & WB.
    主要应用
    • Western Blotting
    • ELISA
    • Immunocytochemistry
    应用说明 Immunocytochemistry using osteoinductive cells; i.e., BFP and Saos-2

    Western blot using osteoinductive cells; i.e., BFP and Saos-2

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Recombinant mouse BMP-4 (Masuhara, 1995).
    克隆 3H2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Specific for bone morphogenetic protein-4 (BMP-4) by Western blot and ELISA. No cross-reactivity with human BMP-2 or human TGF-β1. The antibody reacts with both human and mouse BMP-4 in both reduced and nonreduced conditions.
    Human BMP-4 (accession number P12644) precursor (389 aa, glycosilated) consists of a propeptide (273 aa) and active BMP-4 (116 aa, glycoslyated; MW reduced 17-20 kDa).
    同种型 IgG2b
    品种反应性 RatHumanMouse
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_130851.2
    • NM_001202.3
    • NM_130850.2
    Entrez基因汇总 The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
    基因符号
    • ZYME
    • BMP4
    • BMP2B1
    • BMP2B
    • BMP-4
    • DVR4
    • BMP-2B
    纯化方法 Protein A purfied
    UniProt编号
    • P12644
    UniProt汇总 FUNCTION: SwissProt: P12644 # Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair.
    SIZE: 408 amino acids; 46555 Da
    SUBUNIT: Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD (By similarity).
    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
    TISSUE SPECIFICITY: Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
    SIMILARITY: SwissProt: P12644 ## Belongs to the TGF-beta family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB1049,Anti-Bone Morphogenetic Protein 4 Antibody, clone 3H2

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