merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB012,Anti-Apolipoprotein B Antibody, clone B1

  • merck millipore,默克密理博,MAB012,Anti-Apolipoprotein B Antibody, clone B1

    产品名称：Anti-Apolipoprotein B Antibody, clone B1
    产品型号：MAB012
    This Anti-Apolipoprotein B Antibody, clone B1 is validated for use in ELISA, RIA for the detection of Apolipoprotein B.

    merck millipore,默克密理博,MAB012,Anti-Apolipoprotein B Antibody, clone B1

  • 产品介绍
  • merck millipore,默克密理博,MAB012,Anti-Apolipoprotein B Antibody, clone B1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HELISAMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB012
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Apolipoprotein B Antibody, clone B1
    Alternate Names
    • ApoB
    产品信息
    格式 Purified
    控制
    • Liver tissue
    演示 Liquid, in 0.015 M potassium phosphate buffer with 0.15M NaCl, 0.1% NaN3, pH 7.2.
    应用
    应用 This Anti-Apolipoprotein B Antibody, clone B1 is validated for use in ELISA, RIA for the detection of Apolipoprotein B.
    主要应用
    • ELISA
    应用说明 Competitive RIA

    ELISA

    Optimal working dilution must be determined by the end user.
    生物信息
    克隆 B1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Recognizes Apolipoprotein B. No cross-reactivity to Apo A-I or Apo A-II.
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_000384.2
    Entrez基因汇总 This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination.
    基因符号
    • apoB-100
    • APOB
    • apoB-48
    • FLDB
    纯化方法 Protein A purfied
    UniProt编号
    • P04114
    UniProt汇总 FUNCTION: SwissProt: P04114 # Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.
    SIZE: 4563 amino acids; 515563 Da
    SUBCELLULAR LOCATION: Secreted.
    PTM: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.
    DISEASE: SwissProt: P04114 # Defects in APOB are a cause of familial hypobetalipoproteinemia (FHBL) [MIM:107730]. FHBL is a genetically heterogeneous autosomal co-dominant disorder, associated with reduced plasma concentrations of apoB, LDL and VLDL. Heterozygotes for FHBL are usually asymptomatic with LDL cholesterol and apoB- 100 concentrations less than 50% of those in normal plasma. Homozygotes have extremely low plasma LDL cholesterol and apoB-100 concentrations, and clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia [MIM:200100]. & Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. & Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.SIMILARITY:SwissProt: P04114 ## Contains 1 vitellogenin domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
    包装信息
    数量 500 µg

    merck millipore,默克密理博,MAB012,Anti-Apolipoprotein B Antibody, clone B1

上一件merck millipore产品：merck millipore,默克密理博,MAB8131,Anti-Cytomegalovirus Antibody, immediate early, clone 6F8.2
下一件merck millipore产品：merck millipore,默克密理博,110220,哌肼-1,4-双(2-乙烷磺酸)


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