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merck millipore,默克密理博,04-148,Anti-CLEC9A Antibody, clone 10B4
产品名称：Anti-CLEC9A Antibody, clone 10B4
产品型号：04-148
Detect CLEC9A using this rat monoclonal antibody, Anti-CLEC9A Antibody, clone 10B4 validated for use in western blotting & Flow Cytometry.
merck millipore,默克密理博,04-148,Anti-CLEC9A Antibody, clone 10B4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M FC, WB R Purified Monoclonal Antibody 描述 产品目录编号 04-148 描述 Anti-CLEC9A Antibody, clone 10B4 Alternate Names - CLEC
- C-type lectin domain family 9 member A
- Dendritic cell natural killer lectin group receptor 1
- CLEC9A
背景信息 CLEC9A, also known as Dendritic cell natural killer lectin group receptor 1 (DNGR-1), and encoded by the gene Clec9a/Dngr-1, functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. CLEC9A functions as a SYK-coupled C-type lectin receptor to mediate sensing of necrosis by the principal dendritic-cell subset involved in regulating cross-priming to cell-associated antigens. CLEC9A recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediates the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. CLEC9A is localized to the plasma membrane. CLEC9A is expressed in dendritic cells and has multiple isoforms; isoform 4 is expressed at high levels by CD8+ dendritic cells and at low levels by plasmacytoid DCs but not by other hematopoietic cells. 产品信息 格式 Purified 演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect CLEC9A using this rat monoclonal antibody, Anti-CLEC9A Antibody, clone 10B4 validated for use in western blotting & Flow Cytometry. 主要应用 - Flow Cytometry
- Western Blotting
应用说明 Flow Cytometry Analysis: A representative lot from an independent laboratory detected CLEC9A in mouse Conventional Dendritic cells and on most Plasmacytoid Dendritic cells (Caminschi, I., et al. (2008). Blood. 112(8):3264-3273.). 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse CLEC9A. 克隆 10B4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 同种型 IgG2aκ 品种反应性 Mouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001192292
基因符号 - Dngr-1
- Clec9a
纯化方法 Protein G purified UniProt编号 - Q8BRU4
产品使用声明 质量保证 Evaluated by Western Blotting in mouse lymph node tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected CLEC9A in 10 μg of mouse lymph node tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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