merck millipore,默克密理博,344559,FTI-2628

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Merck Millipore 默克密理愽

merck millipore,默克密理博,344559,FTI-2628 - Calbiochem

经验配方
C₃₁H₃₄N₄O₃S

描述
概述	A cell-permeable benzyl ester prodrug form of FTI-2148 (Cat. No. 344557) that preferentially inhibits protein farnesyltransferase activity (IC₅₀ = 530 nM for mammalian and 1.0 µM for P. falciparum) over protein geranylgeranyltransferase-I (IC₅₀ > 10 µM for mammalian) and displays anti-malarial properties. Potently disrupts Ras farnesylation in H-Ras-transformed NIH 3T3 cells (IC₅₀ = 20 nM) and inhibits the growth of P. falciparum in red blood cells (ED₅₀ = 150 nM). Also suppresses parasitemia in P. berghei-infected mice by 46.1% (50 mg/kg, ip) with no apparent toxicity.
产品目录编号	344559
品牌系列	Calbiochem®
同义词	2-(((5-((1H-Imidazol-4-ylmethyl)-amino)-methyl)-2ʹ-methyl-biphenyl-2-carbonyl)-amino)-4-methylsulfanyl-butyric acid benzyl ester

参考
参考	Carrico, D., et al. 2004. Bioorg. Med. Chem. 12, 6517. Ohkanda, J., et al. 2004. J. Med. Chem. 47, 432.

生物信息
主靶	Protein farnesyltransferase (PFTase)
主靶IC₅₀	530 nM for mammalian and 1.0 µM for P. falciparum protein farnesyltransferase activity
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or MeOH

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,344559,FTI-2628 - Calbiochem

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