merck millipore,默克密理愽
  • merck millipore,默克密理博,07-703,Anti-phospho-STAT3 (Ser727) Antibody

  • merck millipore,默克密理博,07-703,Anti-phospho-STAT3 (Ser727) Antibody

    产品名称：Anti-phospho-STAT3 (Ser727) Antibody
    产品型号：07-703
    Anti-phospho-STAT3 (Ser727) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-STAT3 (Ser727) also known as Signal Transducer & Activator of Transcription 3 & has been tested in WB.

    merck millipore,默克密理博,07-703,Anti-phospho-STAT3 (Ser727) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-703,Anti-phospho-STAT3 (Ser727) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-703
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-STAT3 (Ser727) Antibody
    背景信息 STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway.

    STAT3 has been shown to be activated by IFN-α but not IFN-β. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock out mice was lethal at the early embryonic stage.
    产品信息
    格式 Affinity Purified
    控制
    • PDGF treated (lane 2) 3T3/NIH cell lysate
    应用
    应用 Anti-phospho-STAT3 (Ser727) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-STAT3 (Ser727) also known as Signal Transducer & Activator of Transcription 3 & has been tested in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids 719-729 (C-SNTIDLPM[pS]PR) where pS corresponds to serine 727 of human STAT3 (Signal Transducer and Activator of Transcription 3)
    宿主 Rabbit
    特异性 phospho-STAT3 (Ser727)
    同种型 IgG
    品种反应性 Mouse
    Species Reactivity Note Predicted to cross-react with human, rat, horse, cow, canine, chicken, orangutan, and chimpanzee based on sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_213662.1
    • NM_003150.3
    • NM_139276.2
    Entrez基因汇总 The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
    基因符号
    • MGC16063
    • STAT3
    • APRF
    • FLJ20882
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P40763
    UniProt汇总 FUNCTION: SwissProt: P40763 # Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
    SIZE: 770 amino acids; 88068 Da
    SUBUNIT: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA.
    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
    TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    PTM: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.
    DISEASE: "SwissProt: P40763 # Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures."
    SIMILARITY: SwissProt: P40763 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
    MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 1 year at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-703,Anti-phospho-STAT3 (Ser727) Antibody

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