merck millipore,默克密理博,14-309,PCAF Protein, Active, 50 µg

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merck millipore,默克密理博,14-309,PCAF Protein, Active, 50 µg
产品名称：PCAF Protein, Active, 50 µg
产品型号：14-309
PCAF recombinant GST fusion protein, for use in Histone Acetyltransferase Assays. (HAT).

merck millipore,默克密理博,14-309,PCAF Protein, Active, 50 µg

产品介绍

merck millipore,默克密理博,14-309,PCAF Protein, Active, 50 µg

重要规格表

主要应用	Entrez基因编号	Uni Prot编号
HAT	NM_003884.3	Q92831

描述
产品目录编号	14-309
品牌系列	Upstate
商名	Upstate
描述	PCAF Protein, Active, 50 µg
概述	Recombinant GST fusion protein

应用
应用	PCAF recombinant GST fusion protein, for use in Histone Acetyltransferase Assays. (HAT).
主要应用	Histone Acetyltransferase Assay (HAT)

生物信息
来源	expressed in E. Coli corresponding to amino acids 352-832
特异活性	For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez基因编号	NM_003884.3
Entrez基因汇总	CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
基因符号	CAF PCAF GCN5 GCN5L P P/CAF
UniProt编号	Q92831
UniProt汇总	FUNCTION: SwissProt: Q92831 # Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. SIZE: 832 amino acids; 93013 Da SUBUNIT: Interacts with SIRT1 (By similarity). Interacts with EP300 and CREBBP. Interacts with NCOA1 and NCOA3. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitously expressed but most abundant in heart and skeletal muscle. DOMAIN:SwissProt: Q92831 The bromodomain mediates binding to HIV-1 Tat. SIMILARITY: Belongs to the GCN5 family. & Contains 1 bromo domain. & Contains 1 N-acetyltransferase domain.

产品使用声明
质量保证	routinely evaluated by acetylation of core histones in vitro
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	6 months at -20°C

包装信息
数量	50 µg

merck millipore,默克密理博,14-309,PCAF Protein, Active, 50 µg

上一件merck millipore产品：merck millipore,默克密理博,110220,哌肼-1,4-双(2-乙烷磺酸)
下一件merck millipore产品：merck millipore,默克密理博,344559,FTI-2628 - Calbiochem

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