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merck millipore,默克密理博,IHCR2023-6,IHC Select Anti-CD79a Antibody, prediluted, clone JCB117
产品名称：IHC Select Anti-CD79a Antibody, prediluted, clone JCB117
产品型号：IHCR2023-6
This IHC Select Anti-CD79a Antibody, prediluted, clone JCB117 is validated for use in IH(P) for the detection of CD79a.
merck millipore,默克密理博,IHCR2023-6,IHC Select Anti-CD79a Antibody, prediluted, clone JCB117
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H IH(P) M Purified Monoclonal Antibody 描述 产品目录编号 IHCR2023-6 商名 - Chemicon
- IHC Select
描述 IHC Select® Anti-CD79a Antibody, prediluted, clone JCB117 产品信息 格式 Purified 演示 Monoclonal mouse antibody supplied in liquid format as tissue culture supernatant, diluted in PBS, pH 7.2 with stabilizers, 0.2% Tween 20, and 0.1% ProClin 300 as preservative. 应用 应用 This IHC Select Anti-CD79a Antibody, prediluted, clone JCB117 is validated for use in IH(P) for the detection of CD79a. 主要应用 - Immunohistochemistry (Paraffin)
应用说明 Antibody is prediluted and ready to use for Immunohistochemistry of formalin-fixed, paraffin-embedded tissues.
Pretreatment: Heat Induced Epitope Retrieval (HIER). Recommend Citrate Buffer, pH 6.0 (Cat. No. 21545). No signal was detected without Epitope retrieval.
Incubation: 10 minutes with IHC Select® Detection Kits.
CD79a has been prediluted for use as the primary antibody with Chemicon's IHC Select® Detection Kits and Protocols (Catalog Nos. DAB050, DET-HP1000, APR050, and DET-APR1000), but other supplier's IHC detection systems may be used.生物信息 克隆 JCB117 宿主 Mouse 特异性 B cell antigen receptor complex. The antibody reacts with cells in B cell areas in lymphoid tissue, and with scattered cells in many other tissues. 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_021601.3
- NM_001783.3
Entrez基因汇总 The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-alpha protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. 基因符号 - MB1
- CD79A
- MB-1
- IGA
- Ig-alpha
UniProt编号 - P11912
UniProt汇总 FUNCTION: SwissProt: P11912 # Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src- family tyrosine kinases. Represses BCR signaling during development of immature B cells.
SIZE: 226 amino acids; 25038 Da
SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen- specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts through its phosphorylated ITAM domain with the SH2 domains of SYK which stimulates SYK autophosphorylation and activation. Also interacts, when phosphorylated on Tyr-210, with the SH2 domain of BLNK/SLP65, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK which is necessary for trafficking of the BCR to late endosomes. Interacts with Src-family tyrosine kinases including FYN and LYN, increasing their activity (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity).
TISSUE SPECIFICITY: B-cells.
PTM: Phosphorylated on tyrosine, serine and threonine residues upon B-cell activation. Phosphorylation of tyrosine residues by Src-family kinases is an early and essential feature of the BCR signaling cascade. The phosphorylated tyrosines serve as docking sites for SH2-domain containing kinases, leading to their activation which in turn leads to phosphorylation of downstream targets. Phosphorylation of serine and threonine residues may prevent subsequent tyrosine phosphorylation.
DISEASE: SwissProt: P11912 # Defects in CD79A are a cause of non-Bruton type agammaglobulinemia [MIM:601495]. Agammaglobulinemia is an immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Two different mutations, one at the splice donor site of intron 2 and the other at the splice acceptor site for exon 3, have been identified. Both mutations give rise to a truncated protein.
SIMILARITY: SwissProt: P11912 ## Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 ITAM domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C . Refer to vial for expiration dating. 包装信息 数量 6 mL
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