merck millipore,默克密理愽
  • merck millipore,默克密理博,521236,PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

  • merck millipore,默克密理博,521236,PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

    产品名称：PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem
    产品型号：521236
    The PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 controls the biological activity of PDGFR/VEGFR2 Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,521236,PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,521236,PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₇BrN₂O₃251356-32-8
    描述
    概述 A cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668 (Cat. No. 521235) that is equally potent as SU6668 in inhibiting PDGFR (IC50 = 60 nM against PDGFRβ), while exhibiting more enhanced activity against VEGFR2 and FGFR1 (IC50 = 1.73 and 2.05 µM, respectively) in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ, but is of little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.
    产品目录编号 521236
    品牌系列 Calbiochem®
    同义词 (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI, PDGFR Tyrosine Kinase Inhibitor XV
    参考
    参考 Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
    产品信息
    CAS号 251356-32-8
    形式 Orange solid
    Hill配方 C₁₈H₁₇BrN₂O₃
    化学配方 C₁₈H₁₇BrN₂O₃
    Molar Mass 389.2
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    安全信息
    R相 R: 22-36/37/38

    Harmful if swallowed.
    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36-45

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,521236,PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

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