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品种反应性 主要应用 宿主 格式 抗体类型 H, M, R, Xn WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1817 描述 Anti-phospho-SRPK2 (Ser494) Antibody Alternate Names - SR-protein-specific kinase 2
- Serine/threonine-protein kinase SRPK2
- SFRS protein kinase 2
- Serine/arginine-rich protein-specific kinase 2
背景信息 Along with Serine/threonine protein kinase 2 (SRPK2), SRPK1 phosphorylates serine residues found in RS-domain-containing proteins, such as SFRS1 and SFRS2. These kinases also phosphorylate the same serine residues on the HBV core protein both in vitro and in vivo. The cytoplasmic proteins are critical for nuclear import of SR proteins in a phosphorylation-dependent manner. Additionally, they mediate the trafficking of splicing factors and play a role in spliceosome assembly and mitogenesis. 产品信息 格式 Affinity Purified 控制 - Untreated and insulin treated HepG2 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-phospho-SRPK2 (Ser494) Antibody is an antibody against phospho-SRPK2 (Ser494) for use in WB, PIA. 主要应用 - Western Blotting
应用说明 Peptide Inhibition Analysis: 1 µg/mL from a representative lot detected SRPK2 in 10 µg of insulin treated HepG2 cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the protein kinase domain of SRPK2 phosphorylated at Ser494. 表位 Protein kinase domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody is specific for the protein kinase domain of SRPK2 phosphorylated at Ser494, independent of observed phosphorylation at Ser497. 品种反应性 HumanMouseRatXenopus Species Reactivity Note Demonstrated to react with Human and Mouse. Predicted to react with Rat and Xenopus based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_872633
基因符号 - SRPK2
修改 - Phosphorylation
纯化方法 Affinity purified UniProt编号 - P78362
UniProt汇总 FUNCTION: Phosphorylates RS domain-containing proteins, such as SFRS1 and SFRS2 on serine residues. Role in spliceosome assembly and in mediating the trafficking of splicing factors. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium.
ENZYME REGULATION: Activated by phosphorylation on Ser-52 and Ser-588.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
TISSUE SPECIFICITY: Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.产品使用声明 质量保证 Evaluated by Western Blot in untreated and insulin treated HepG2 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected SRPK2 in 10 µg HepG2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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