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merck millipore,默克密理博,219332,β-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem
产品名称：β-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem
产品型号：219332
The β-Catenin/Tcf Inhibitor III, iCRT3 controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applications.
merck millipore,默克密理博,219332,β-Catenin/Tcf Inhibitor III, iCRT3 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₃H₂₆N₂O₂S 描述 概述 A cell-permeable oxazole compound that acts as a selective CRT (β-catenin responsive transcription) inhibitor (IC50 = 8.2 nM against Wnt3a-dependent SuperTopFlash STF16-luc reporter activity in HEK293 cultures) by interfering with β-cat-TCF4 interaction via direct β-catenin (β-cat) binding, while exhibiting much reduced activity against Hedgehog, Jak/Stat, or Notch signaling pathway-dependent transcription activation. Effectively inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25 to 75 µM), and selectively inhibits the proliferation of HCT116 (75 µM), HT29 (75 µM), and several primary human colon cancer cultures (6.25 to 100 µg/ml; average IC50 ~36 µg/ml) that require sustained Wnt/CRT activity for survival. 产品目录编号 219332 品牌系列 Calbiochem®
同义词 Wnt Pathway Inhibitor VIII, 2-(((2-(4-Ethylphenyl)-5-methyl-1,3-oxazol-4-yl)methyl)sulfanyl)-N-(2-phenylethyl)acetamide, Inhibitor of β-Catenin Responsive Transcription, C3 参考 参考 Lee, E., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 15710.
Gonsalves, F.C., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 5954.产品信息 形式 Tan powder Hill配方 C₂₃H₂₆N₂O₂S 化学配方 C₂₃H₂₆N₂O₂S Molar Mass 394.5 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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